Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat.
Komaki A, Khalili A, Salehi I, Shahidi S, Sarihi A. · 2014
View Original AbstractProlonged exposure to ELF-EMFs increased LTP induction in rats, with a marked change suggested in synaptic plasticity of the PP-DG synapses.
Plain English Summary
Researchers divided twenty-nine adult male Wistar rats into three groups: an ELF-EMF exposed group, a sham group, and a control group. The exposed rats received a 50 Hz, 100 micro Tesla magnetic field for 90 consecutive days at 2 hours per day. Prolonged exposure to ELF-EMFs increased LTP induction, and there was a significant difference in the slope of EPSP and amplitude of PS between the ELF-EMF group and other groups. The researchers' data suggest that exposure to ELF-EMFs produces a marked change in the synaptic plasticity generated in synapses of the PP-DG.
Why This Matters
LTP in the hippocampal area was induced by high-frequency stimulation. A bipolar stimulating and recording electrode was implanted into the perforant pathway and dentate gyrus, respectively. No significant difference in paired-pulse ratio before and after high-frequency stimulation in the ELF-EMF group suggests a postsynaptic expression site of LTP.
Exposure Details
- Magnetic Field
- 0.1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 90 consecutive days (2 h/day)
Exposure Context
This study used 0.1 mT for magnetic fields:
- 5Kx above the Building Biology guideline of 0.2 mG
- 1Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In the present study, we investigated whether ELF-EMFs can change induction of long-term potentiation (LTP) and paired-pulse ratio (PPR) in the rat hippocampal area.
Twenty-nine adult male Wistar rats were divided into 3 groups (ELF-EMF exposed, sham and control gro...
LTP in hippocampal area was induced by high-frequency stimulation (HFS). Prolonged exposure to ELF-E...
In conclusion, our data suggest that exposure to ELF-EMFs produces a marked change in the synaptic plasticity generated in synapses of the PP-DG. No significant difference in PPR of ELF-EMF group before and after HFS suggests a postsynaptic expression site of LTP.
Show BibTeX
@article{a_2014_effects_of_exposure_to_267,
author = {Komaki A and Khalili A and Salehi I and Shahidi S and Sarihi A. },
title = {Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat.},
year = {2014},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0006899314004193},
}