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Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line.

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López-Furelos A, Salas-Sánchez AA, Ares-Pena FJ, Leiro-Vidal JM, López-Martín E. · 2018

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The study found that phagocytic activity of macrophages decreased in all exposure groups over time, while combined radiofrequency exposure increased inflammatory and cytoprotective markers.

Plain English Summary

Summary written for general audiences

Researchers exposed RAW 264.7 macrophage cells to single or combined radiofrequency signals at 900 and 2450 MHz for 4, 24, 48, or 72 hours in a GTEM chamber. They measured cell viability, nitric oxide production, HSP70 and TNF-α expression, and phagocytic activity. Phagocytic activity declined with longer exposure, while combined exposure raised HSP70 at 48 hours and significantly increased nitric oxide and TNF-α at 72 hours.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 and 2450 MHz Duration: 4, 24, 48, or 72 h

Study Details

The aim of this study was to determine whether exposure to radiation from single or multiple radio-frequency (RF) signals at 900 and 2450 MHz would induce effects in the RAW 264.7 cell line

Cell cultures were exposed to single or combined RF for 4, 24, 48, or 72 h in a GTEM electromagnetic...

NO production increased after 48 h exposure at 2450 MHz, compared with controls. The group subjected...

Our results indicated a decrease in phagocytic activity and an increase in inflammatory, cytoprotective, and cytotoxic responses in macrophages after continuous and combined exposure of multiple RF signals. Multiple RF interact in everyday life, the immune response in humans is unknown.

Cite This Study
López-Furelos A, Salas-Sánchez AA, Ares-Pena FJ, Leiro-Vidal JM, López-Martín E. (2018). Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line. Int J Radiat Biol. (6):607-618, 2018.
Show BibTeX
@article{a_2018_exposure_to_radiation_from_1667,
  author = {López-Furelos A and Salas-Sánchez AA and Ares-Pena FJ and Leiro-Vidal JM and López-Martín E.},
  title = {Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line.},
  year = {2018},
  doi = {10.1080/09553002.2018.1465610},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2018.1465610},
}
DOI: 10.1080/09553002.2018.1465610

Cited By (20 papers)

Quick Questions About This Study

The study used the RAW 264.7 macrophage cell line.
Cells were exposed for 4, 24, 48, or 72 hours.
Phagocytic activity of macrophages decreased in all groups as exposure time increased.
The authors noted that multiple radiofrequency signals interact in everyday life, but the human immune response is unknown.