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Brain & Nervous System

Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field

No Effects Found

Canseven AG, Keskil ZA, Keskil S, Seyhan N. · 2007

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Pre- and post-drug exposure to a 50 Hz, 0.2 mT magnetic field did not alter pentylenetetrazol-induced seizures or mortality in mice.

Plain English Summary

Summary written for general audiences

Researchers tested whether a 50 Hz, 0.2 mT magnetic field given before or after drug administration affected seizures induced by pentylenetetrazol in mice. The magnetic field was generated by a pair of Helmholtz coils and seizures were induced by intraperitoneal injection of pentylenetetrazol at 60 mg/kg. Forty-eight adult female mice were used and latency to seizure, total seizure duration, and mortality were recorded. Neither pre- nor post-drug magnetic field exposure had any effect on seizures or mortality rates.

Why This Matters

The authors concluded that the study did not support any therapeutic potential of a 50 Hz, 0.2 mT magnetic field for epilepsy. The results failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT magnetic field for epilepsy.

Exposure Details

Magnetic Field
0.2 mT
Source/Device
50 Hz

Exposure Context

This study used 0.2 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.2 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice.

MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitonea...

Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induce...

The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.

Cite This Study
Canseven AG, Keskil ZA, Keskil S, Seyhan N. (2007). Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field Radiat Biol. 83(4):231-235, 2007.
Show BibTeX
@article{ag_2007_pentylenetetrazolinduced_seizures_are_not_2824,
  author = {Canseven AG and Keskil ZA and Keskil S and Seyhan N.},
  title = {Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field},
  year = {2007},
  doi = {10.1080/09553000701206676},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553000701206676},
}
DOI: 10.1080/09553000701206676

Cited By (5 papers)

Quick Questions About This Study

The exposure was a 50 Hz, 0.2 mT magnetic field. The field was generated by a pair of Helmholtz coils.
Seizures were induced by intraperitoneal injection of pentylenetetrazol at a dose of 60 mg/kg.
Latency to seizure, total seizure duration, and mortality were recorded for each mouse.
The study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT magnetic field for epilepsy.
A total of 48 locally bred adult female mice weighing 25 to 35 grams were used.