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Mobile-phone Radiation-induced Perturbation of Gene-expression Profiling, Redox Equilibrium and Sporadic-apoptosis Control in the Ovary of Drosophila melanogaster.

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Manta AK, Papadopoulou D, Polyzos AP, Fragopoulou AF, Skouroliakou AS, Thanos D, Stravopodis DJ, Margaritis LH. · 2017

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Exposing fruit flies to mobile-phone radiation for 30 minutes was associated with increased reactive oxygen species, changes in gene expression, and more apoptotic follicles in the ovary.

Plain English Summary

Summary written for general audiences

Researchers exposed four-day-old adult female Drosophila melanogaster to mobile-phone radiation for 30 minutes at a SAR of 0.15 W/kg and a SAE of 270 J/kg. Reactive oxygen species levels in follicles of pre-choriogenic stages were found to increase by 1.6-fold immediately after the end of exposure. Sporadically generated apoptotic follicles showed an averaged 2-fold upregulation in their sub-population mass, 4 hours after irradiation. Microarray analysis revealed 168 genes being differentially expressed 2 hours after exposure, associated with processes such as basic metabolism, stress response, and apoptotic death.

Why This Matters

Reactive oxygen species levels, apoptosis in follicles, and genome-wide gene expression changes were assayed in parallel in the ovary. Each outcome was measured at a different time point, allowing researchers to observe a sequence: a rise in reactive oxygen species immediately after exposure, gene-expression changes at 2 hours, and increased apoptotic follicles at 4 hours. The researchers described the transcriptional changes as "global, systemic and non-targeted," suggesting the gene-expression response was widespread. The authors described the radiation as a "unique type of pulsed radiation" that "seems capable of mobilizing critical cytopathic mechanisms, and altering fundamental genetic programs and networks in D. melanogaster."

Exposure Details

SAR
0.15 W/kg
Exposure Duration
30 min

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.15 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 11 times higher than this level

Study Details

The aim of this study is to observe Mobile-phone Radiation-induced Perturbation of Gene-expression Profiling, Redox Equilibrium and Sporadic-apoptosis Control in the Ovary of Drosophila melanogaster.

Drosophila melanogaster four days-old adult female flies were exposed for 30 min to radiation emitte...

ROS cellular contents were found to increase by 1.6-fold (x), immediately after the end of exposure,...

This unique type of pulsed radiation, mainly being derived from daily used mobile phones, seems capable of mobilizing critical cytopathic mechanisms, and altering fundamental genetic programs and networks in D. melanogaster

Cite This Study
Manta AK, Papadopoulou D, Polyzos AP, Fragopoulou AF, Skouroliakou AS, Thanos D, Stravopodis DJ, Margaritis LH. (2017). Mobile-phone Radiation-induced Perturbation of Gene-expression Profiling, Redox Equilibrium and Sporadic-apoptosis Control in the Ovary of Drosophila melanogaster. Fly (Austin). 11(2):75-95, 2017.
Show BibTeX
@article{ak_2017_mobilephone_radiationinduced_perturbation_of_548,
  author = {Manta AK and Papadopoulou D and Polyzos AP and Fragopoulou AF and Skouroliakou AS and Thanos D and Stravopodis DJ and Margaritis LH.},
  title = {Mobile-phone Radiation-induced Perturbation of Gene-expression Profiling, Redox Equilibrium and Sporadic-apoptosis Control in the Ovary of Drosophila melanogaster.},
  year = {2017},
  doi = {10.1080/19336934.2016.1270487},
  url = {https://www.tandfonline.com/doi/full/10.1080/19336934.2016.1270487},
}
DOI: 10.1080/19336934.2016.1270487

Cited By (16 papers)

Quick Questions About This Study

Four-day-old adult female Drosophila melanogaster were exposed for 30 minutes to radiation from a commercial mobile phone at a SAR of 0.15 W/kg and a SAE of 270 J/kg.
Reactive oxygen species levels increased by 1.6-fold in follicles of pre-choriogenic stages immediately after the end of exposure.
Microarray analysis revealed 168 genes being differentially expressed 2 hours after exposure, at a threshold of at least 1.25-fold change and P less than 0.05.
Sporadically generated apoptotic follicles showed an averaged 2-fold upregulation in their sub-population mass, 4 hours after irradiation.
The differentially expressed genes were associated with basic metabolism and cellular processes related to stress response and apoptotic death.