Non-thermal DNA breakage by mobile-phone radiation (1800MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.
Diem E, Schwarz C, Adlkofer F, Jahn O, Rudiger H. · 2005
View Original Abstract1800 MHz RF-EMF induced DNA single- and double-strand breaks in human fibroblasts and rat granulosa cells, with researchers concluding the damage was not thermal.
Plain English Summary
Researchers exposed cultured human diploid fibroblasts and transformed GFSH-R17 rat granulosa cells to 1800 MHz RF-EMF at SAR levels of 1.2 or 2 W/kg, using both intermittent and continuous exposures. DNA strand breaks were determined by means of the alkaline and neutral comet assay. Effects occurred after 16 h exposure in both cell types, and intermittent exposure showed a stronger effect in the comet assay than continuous exposure. The researchers concluded that the induced DNA damage cannot be based on thermal effects.
Why This Matters
The cells studied were cultured human diploid fibroblasts and cultured rat granulosa cells. Exposures were conducted at SAR values of 1.2 or 2 W/kg, with sessions lasting 4, 16, or 24 hours. Intermittent exposure followed a pattern of 5 minutes on and 10 minutes off. Both single-strand and double-strand DNA breaks were detected, and the intermittent schedule produced a stronger response in the comet assay than continuous-wave exposure.
Exposure Details
- SAR
- 1.2, 2 W/kg
- Source/Device
- 1800 MHz mobile phone radiation
- Exposure Duration
- 5 min on/10 min off, for 4, 16 and 24 h
Exposure Context
This study used 1.2, 2 W/kg for SAR (device absorption):
- 3x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this project was to study the non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.
Cultured human diploid fibroblasts and cultured rat granulosa cells were exposed to intermittent and...
RF-EMF exposure (1800 MHz; SAR 1.2 or 2 W/kg; different modulations; during 4, 16 and 24 h; intermit...
Therefore we conclude that the induced DNA damage cannot be based on thermal effects.
Show BibTeX
@article{e_2005_nonthermal_dna_breakage_by_35,
author = {Diem E and Schwarz C and Adlkofer F and Jahn O and Rudiger H.},
title = {Non-thermal DNA breakage by mobile-phone radiation (1800MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.},
year = {2005},
url = {http://www.sciencedirect.com/science/article/pii/S1383571805000896},
}