Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro
Sun LX, Yao K, He JL, Lu DQ, Wang KJ, Li HW. · 2006
View Original AbstractNo or repairable DNA damage was observed in cultured LECs at SAR at or below 3 W/kg, while damage at 4 W/kg was irreversible.
Plain English Summary
Cultured LECs were exposed to 217 Hz modulated 1.8 GHz microwave radiation at specific absorption rates of 0, 1, 2, 3, and 4 W/kg for 2 hours. DNA single strand breaks were detected with comet assay at 0, 30, 60, 120, and 240 minutes after irradiation. At 1 and 2 W/kg, the difference in DNA breaks between exposure and sham exposure groups was not significant at any detection time. At 3 and 4 W/kg, differences were significant immediately and 30 minutes after irradiation, with the difference disappearing after one hour in the 3 W/kg group but persisting in the 4 W/kg group.
Why This Matters
The study aimed to investigate DNA damage of LECs caused by acute exposure to low-power 217 Hz modulated 1.8 GHz microwave radiation and DNA repair. The indexes used to assess DNA damage were tail length and tail moment. No or repairable DNA damage was observed after 2 hours of 1.8 GHz microwave irradiation on LECs when SAR was at or below 3 W/kg. The DNA damages caused by 4 W/kg irradiation were irreversible.
Exposure Details
- SAR
- 0, 1, 2, 3 and 4 W/kg
- Source/Device
- 1.8 GHz mobile phone (217 Hz modulated)
- Exposure Duration
- 2h
Exposure Context
This study used 0, 1, 2, 3 and 4 W/kg for SAR (device absorption):
- 2.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To investigate the DNA damage of human lens epithelial cells (LECs) caused by acute exposure to low-power 217 Hz modulated 1.8 GHz microwave radiation and DNA repair.
Cultured LECs were exposed to 217 Hz modulated 1.8 GHz microwave radiation at SAR (specific absorpti...
The difference in DNA-breaks between the exposure and sham exposure groups induced by 1 and 2 W/kg i...
No or repairable DNA damage was observed after 2 hour irradiation of 1.8 GHz microwave on LECs when SAR < or = 3 W/kg. The DNA damages caused by 4 W/kg irradiation were irreversible.
Show BibTeX
@article{lx_2006_effect_of_acute_exposure_28,
author = {Sun LX and Yao K and He JL and Lu DQ and Wang KJ and Li HW.},
title = {Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro},
year = {2006},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16978512},
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