8-Oxo-7, 8-dihydro-2'-deoxyguanosine as a biomarker of DNA damage by mobile phone radiation.
Khalil AM, Gagaa M, Alshamali A. · 2012
View Original AbstractExposure to mobile phone radio frequency radiation raised urinary 8-oxodG levels in adult male rats at most time points, with the peak suggesting DNA repair.
Plain English Summary
Researchers exposed adult male Sprague-Dawley rats to mobile phone radio frequency radiation from a GSM signal generator at a whole-body specific absorption rate of 1.0 W/kg for 2 hours. Urinary levels of 8-oxodG, described as one major form of oxidative DNA damage, were significantly elevated in exposed rats compared to controls at most time points.
Why This Matters
Twenty-four rats were divided into an exposed group and a control group of 12 rats each, across three independent experiments. Urine was collected while rats were housed in a metabolic cage, at 0.5, 1.0, 2.0, and 4.0 hours from the beginning of exposure. In the control group, the signal generator was left in the turn-off position. The one time point that did not show a significant elevation was the urine collected in the last half hour of exposure. Concentrations of 8-oxodG were standardized against creatinine to account for differences in urine concentration.
Exposure Details
- SAR
- 1 W/kg
- Source/Device
- GSM Mobile
- Exposure Duration
- 2h
Exposure Context
This study used 1 W/kg for SAR (device absorption):
- 2.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We examined the effect of exposure to mobile phone 1800 MHz radio frequency radiation (RFR) upon the urinary excretion of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), one major form of oxidative DNA damage, in adult male Sprague-Dawley rats.
Twenty-four rats were used in three independent experiments (RFR exposed and control, 12 rats, each)...
With the exception of the urine collected in the last half an hour of exposure, significant elevatio...
Significant differences were seen overall across time points of urine collection with a maximum at 1 h after exposure, suggesting repair of the DNA lesions leading to 8-oxodG formation.
Show BibTeX
@article{am_2012_8oxo7_8dihydro2deoxyguanosine_as_a_4,
author = {Khalil AM and Gagaa M and Alshamali A.},
title = {8-Oxo-7, 8-dihydro-2'-deoxyguanosine as a biomarker of DNA damage by mobile phone radiation.},
year = {2012},
url = {http://het.sagepub.com/content/31/7/734.short},
}