Possible effects of melatonin and omega-3 on the obesity-related hypothalamic nuclei of the electromagnetic field-exposed offspring rats: a stereological and immunohistochemical analysis
Altun G, Kaplan S · 2025
Prenatal exposure to 900 MHz EMF reduced neuron numbers in the arcuate nucleus and increased anxiety-like behavior in offspring rats.
Plain English Summary
Offspring hypothalamic neurons were analyzed using stereological, immunohistochemical, and ultrastructural methods, and anxiety and locomotor behaviors were assessed. EMF exposure reduced neuron numbers in the arcuate nucleus and increased anxiety-like behavior in offspring. Oxidative stress markers were altered and NPY immunoreactivity was stronger in EMF-exposed offspring, while melatonin and omega-3 did not show clear therapeutic effects.
Why This Matters
The study aimed to evaluate neuronal changes in hypothalamic nuclei related to obesity and to test the protective roles of melatonin and omega-3. Melatonin was given at 50 mg/kg/day and omega-3 at 0.93 g/mL via gavage. The authors concluded that prenatal exposure to mobile phones may cause hypothalamic neurodegeneration and alter FTO and NPY expression, and that melatonin and omega-3 therapeutic effects were not apparent.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{altun_g_kaplan_s_ce2292,
author = {Altun G and Kaplan S},
title = {Possible effects of melatonin and omega-3 on the obesity-related hypothalamic nuclei of the electromagnetic field-exposed offspring rats: a stereological and immunohistochemical analysis},
year = {2025},
doi = {10.3389/fpubh.2025.1583097},
}