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Oxidative Stress

Cell oxidation–reduction imbalance after modulated radiofrequency radiation.

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Marjanovic AM, Pavicic I, Trosic I, · 2015

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ROS levels significantly increased in V79 cells after 10 minutes of exposure to a modulated radiofrequency field, suggesting the radiation might cause impairment in cell oxidation-reduction equilibrium.

Plain English Summary

Summary written for general audiences

Researchers evaluated the influence of a modulated radiofrequency field of 1800 MHz, strength of 30 V/m on oxidation-reduction processes within the cell. V79 cell line samples were irradiated for 10, 30, and 60 minutes, with a specific absorption rate calculated to be 1.6 W/kg. ROS levels significantly increased after 10 minutes of exposure, then decreased after 30 minutes, which researchers associated with antioxidant defence mechanism activation. Metabolic activity and total protein content in exposed cells did not differ significantly from control samples.

Why This Matters

The radiofrequency field was generated within a Gigahertz Transversal Electromagnetic Mode cell equipped by signal generator, modulator, and amplifier. Reactive oxygen species were marked with fluorescent probe 2',7'-dichlorofluorescin diacetate and measured by means of plate reader device. Concentrations of carbonyl derivates, a product of protein oxidation, insignificantly but continuously increase with duration of exposure. The researchers concluded that, under the given laboratory conditions, modulated RF radiation might cause impairment in cell oxidation-reduction equilibrium within the growing cells.

Exposure Details

SAR
1.6 W/kg
Electric Field
30 V/m
Source/Device
1800 MHz
Exposure Duration
10, 30, and 60 min

Exposure Context

This study used 30 V/m for electric fields:

This study used 1.6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1.6 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

Aim of this study was to evaluate an influence of modulated radiofrequency field (RF) of 1800 MHz, strength of 30 V/m on oxidation–reduction processes within the cell

The assigned RF field was generated within Gigahertz Transversal Electromagnetic Mode cell equipped ...

In comparison with control cell samples, metabolic activity and total protein content in exposed cel...

In conclusion, under the given laboratory conditions, modulated RF radiation might cause impairment in cell oxidation–reduction equilibrium within the growing cells.

Cite This Study
Marjanovic AM, Pavicic I, Trosic I, (2015). Cell oxidation–reduction imbalance after modulated radiofrequency radiation. Electromagn Biol Med. 34(4):381-386, 2015.
Show BibTeX
@article{am_2015_cell_oxidationreduction_imbalance_after_550,
  author = {Marjanovic AM and Pavicic I and Trosic I and},
  title = {Cell oxidation–reduction imbalance after modulated radiofrequency radiation.},
  year = {2015},
  doi = {10.3109/15368378.2014.948184},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2014.948184},
}
DOI: 10.3109/15368378.2014.948184

Cited By (20 papers)

Quick Questions About This Study

The study used the V79 cell line, irradiated for 10, 30, and 60 minutes.
ROS levels significantly increased after 10 minutes of exposure (p < 0.05).
Metabolic activity and total protein content in exposed cells did not differ significantly from control cell samples.
The researchers concluded that modulated RF radiation might cause impairment in cell oxidation-reduction equilibrium within the growing cells.
The specific absorption rate was calculated to be 1.6 W/kg.