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The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors

Bioeffects Seen

Hajipour Verdom B, Abdolmaleki P, Behmanesh M. · 2018

A static magnetic field combined with 0.1 µM doxorubicin decreased viability and proliferation of cancer and normal cells in a synergistic manner.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of a homogenous static magnetic field (SMF) on doxorubicin-induced toxicity and proliferation rate of cancer cells. SMF alone decreased cell viability and proliferation rate in MCF-7 and HFF cells, similar to doxorubicin alone. The combination of 10 mT SMF and 0.1 µM doxorubicin decreased viability and proliferation of cancer and normal cells in a synergistic manner. The findings suggest that SMF can decrease the required dose of chemotherapy drugs such as doxorubicin and thereby decrease their side effects.

Why This Matters

SMF boosted the generation and lifetime of reactive oxygen species (ROS) at a low dose of doxorubicin. Despite a high level of glutathione (GSH) in cancer cells, SMF overcame GSH-mediated drug resistance. SMF exposure was also associated with a 50% decrease in iron content of cells, which the researchers attributed to iron homeostasis.

Exposure Details

Magnetic Field: 5, 10, 15 and 20 mT
Exposure Duration: 24 and 48 h

Exposure Context

This study used 5, 10, 15 and 20 mT for magnetic fields:

250Kx above the Building Biology guideline of 0.2 mG
50Kx above the BioInitiative Report recommendation of 1 mG

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Details

Here, we investigated the potential effects of homogenous static magnetic field (SMF) on DOXO-induced toxicity and proliferation rate of cancer cells.

The results indicated that SMF similar to DOXO decreased the cell viability as well as the prolifera...

In conclusion, these findings suggest that SMF can decrease required dose of chemotherapy drugs such as DOXO and thereby decrease their side effect.

Cite This Study

Hajipour Verdom B, Abdolmaleki P, Behmanesh M. (2018). The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors Sci Rep. 8(1):990, 2018.

Show BibTeX

@article{b_2018_the_static_magnetic_field_382,
  author = {Hajipour Verdom B and Abdolmaleki P and Behmanesh M.},
  title = {The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors},
  year = {2018},
  
  url = {https://www.nature.com/articles/s41598-018-19247-8},
}

Quick Questions About This Study

The study measured cell viability and proliferation rate in MCF-7 and HFF cells.

The combination tested was 10 mT SMF together with 0.1 µM doxorubicin.

SMF exposure decreased iron content of cells by 50%, which the researchers attributed to iron homeostasis.

The findings suggest that SMF can decrease the required dose of chemotherapy drugs such as doxorubicin and thereby decrease their side effects.

Despite high glutathione levels in cancer cells, SMF boosted ROS generation and lifetime at a low dose of doxorubicin, overcoming GSH-mediated drug resistance.