Power frequency magnetic field promotes a more malignant phenotype in neuroblastoma cells via redox-related mechanisms.
Falone S, Santini S Jr, Cordone V, Cesare P, Bonfigli A, Grannonico M, Di Emidio G, Tatone C, Cacchio M, Amicarelli F. · 2017
View Original AbstractAn ELF magnetic field induced a proliferative and survival advantage in neuroblastoma cells by activating antioxidative and detoxification cytoprotective pathways.
Plain English Summary
Researchers investigated whether a 50 Hz, 1 mT ELF magnetic field promoted hyperproliferation and improved defence against reactive oxygen species in SH-SY5Y human neuroblastoma cells. The field activated antioxidant and detoxification pathways linked to more aggressive cell behavior, along with upregulation of major sirtuins and increased NRF2 signaling. Exposure to a 50 Hz magnetic field as low as 100 µT may still be able to alter cancer cell behavior and responses to clinically relevant drugs.
Why This Matters
The study used SH-SY5Y human neuroblastoma cells exposed to a 50 Hz, 1 mT ELF magnetic field. The researchers concluded that the biology of neuro-derived malignant cells is altered by ELF-MF exposure, potentially providing a proliferative or survival advantage through an enduring activation of redox-responsive pathways.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50 Hz
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We investigated whether the hyperproliferation that is induced in SH-SY5Y human neuroblastoma cells by a 50 Hz, 1 mT ELF magnetic field was supported by improved defence towards reactive oxygen species (ROS) and xenobiotics, as well as by reduced vulnerability against both H2O2 and anti-tumor ROS-generating drug doxorubicin.
ELF-MF induced a proliferative and survival advantage by activating key redox-responsive antioxidati...
In conclusion, our study reports that the biology of neuro-derived malignant cells is altered by ELF-MF exposure. This could provide proliferative or survival advantage through an enduring activation of major redox-responsive antioxidative and detoxification cytoprotective pathways that are associated with more aggressive/resistant behavior.
Show BibTeX
@article{s_2017_power_frequency_magnetic_field_358,
author = {Falone S and Santini S Jr and Cordone V and Cesare P and Bonfigli A and Grannonico M and Di Emidio G and Tatone C and Cacchio M and Amicarelli F.},
title = {Power frequency magnetic field promotes a more malignant phenotype in neuroblastoma cells via redox-related mechanisms.},
year = {2017},
url = {https://www.nature.com/articles/s41598-017-11869-8},
}