Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons.
Yin C, Luo X, Duan Y, Duan W, Zhang H, He Y, Sun G, Sun X · 2016
View Original AbstractLotus seedpod procyanidins protected rat hippocampal neurons against damage caused by extremely low frequency electromagnetic field exposure in a lab study.
Plain English Summary
Researchers investigated whether lotus seedpod procyanidins (LSPCs) could protect primary cultured rat hippocampal neurons from extremely low frequency electromagnetic field (ELF-EMF)-induced neurotoxicity. ELF-EMF exposure significantly decreased cell viability and increased the number of apoptotic cells compared with control. LSPCs evidently protected the hippocampal neurons against ELF-EMF-induced cell damage, and the researchers concluded this occurred through inhibiting oxidative stress and a mitochondrial apoptotic pathway.
Why This Matters
Researchers measured several markers of cellular harm, including cell viability, the number of apoptotic cells, superoxide dismutase, and malondialdehyde. LSPCs also inhibited the elevation of intracellular reactive oxygen species and calcium levels, and prevented disruption of mitochondrial membrane potential induced by ELF-EMF exposure. LSPCs were found to alleviate DNA damage, block cell cycle arrest at S phase, and inhibit apoptosis and necrosis of hippocampal neurons under ELF-EMF exposure. At the protein level, LSPCs up-regulated Bcl-2 and Bcl-xl proteins and suppressed Bad and Bax proteins that had been affected by ELF-EMF exposure.
Exposure Details
- Magnetic Field
- 8 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 90 minutes
Exposure Context
This study used 8 mT for magnetic fields:
- 400Kx above the Building Biology guideline of 0.2 mG
- 80Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The present study investigated the protective effects of lotus seedpod procyanidins (LSPCs) on extremely low frequency electromagnetic field (ELF-EMF)-induced neurotoxicity in primary cultured rat hippocampal neurons and the underlying molecular mechanism.
The results of MTT, morphological observation, superoxide dismutase (SOD) and malondialdehyde (MDA) ...
In conclusion, these findings revealed that LSPCs protected against ELF-EMF-induced neurotoxicity through inhibiting oxidative stress and mitochondrial apoptotic pathway.
Show BibTeX
@article{c_2016_neuroprotective_effects_of_lotus_484,
author = {Yin C and Luo X and Duan Y and Duan W and Zhang H and He Y and Sun G and Sun X},
title = {Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons.},
year = {2016},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0753332216304516},
}