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Effects of acute and chronic exposure to both 900 MHz and 2100 MHz electromagnetic radiation on glutamate receptor signaling pathway.

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Gökçek-Saraç Ç, Er H, Kencebay Manas C, Kantar Gok D, Özen Ş, Derin N · 2017

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The study found that chronic exposure to 900 and 2100 MHz RF-EMR significantly increased hippocampal enzyme levels compared to acute exposure, and 2100 MHz exposure produced higher levels than 900 MHz in both exposure durations.

Plain English Summary

Summary written for general audiences

Rats were exposed to 900 and 2100 MHz RF-EMR for 2 h/day for either 1 week (acute) or 10 weeks (chronic). The study measured hippocampal levels and activity of PKA, CaMKIIα, CREB, and p44/42 MAPK from NMDAR-related signaling pathways using Western blotting and activity assays. Chronic exposure produced significantly higher enzyme levels than acute exposure at both frequencies, and 2100 MHz exposure produced higher levels than 900 MHz in both acute and chronic groups.

Why This Matters

The authors concluded that both exposure duration and carrier frequency had different effects on hippocampal protein expression in Wistar rats. They suggested that these findings might encourage further research on protection against RF-EMR exposure.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.10 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.10 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 and 2100 MHz RF-EMR Duration: 2 h/day for acute (1 week)(900MHz) or chronic (10 weeks) (2100 MHz)

Study Details

To demonstrate the molecular effects of acute and chronic exposure to both 900 and 2100 MHz radiofrequency electromagnetic radiation (RF-EMR) on the hippocampal level/activity of some of the enzymes – including PKA, CaMKIIα, CREB, and p44/42 MAPK – from N-methyl-D-aspartate receptor (NMDAR)-related signaling pathways.

Rats were divided into the following groups: sham rats, and rats exposed to 900 and 2100 MHz RF-EMR ...

The obtained results revealed that the hippocampal level/activity of selected enzymes was significan...

The present study provides experimental evidence that both exposure duration (1 week versus 10 weeks) and different carrier frequencies (900 vs. 2100 MHz) had different effects on the protein expression of hippocampus in Wistar rats, which might encourage further research on protection against RF-EMR exposure.

Cite This Study
Gökçek-Saraç Ç, Er H, Kencebay Manas C, Kantar Gok D, Özen Ş, Derin N (2017). Effects of acute and chronic exposure to both 900 MHz and 2100 MHz electromagnetic radiation on glutamate receptor signaling pathway. Int J Radiat Biol. 93(9):980-989, 2017.
Show BibTeX
@article{c_2017_effects_of_acute_and_1494,
  author = {Gökçek-Saraç Ç and Er H and Kencebay Manas C and Kantar Gok D and Özen Ş and Derin N},
  title = {Effects of acute and chronic exposure to both 900 MHz and 2100 MHz electromagnetic radiation on glutamate receptor signaling pathway.},
  year = {2017},
  doi = {10.1080/09553002.2017.1337279},
  url = {https://www.tandfonline.com/doi/full/10.1080/09553002.2017.1337279?scroll=top&needAccess=true},
}
DOI: 10.1080/09553002.2017.1337279

Cited By (14 papers)

Quick Questions About This Study

Rats were exposed to 900 and 2100 MHz RF-EMR for 2 h/day for either 1 week (acute) or 10 weeks (chronic).
The study measured hippocampal levels and activity of PKA, CaMKIIα, CREB, and p44/42 MAPK from NMDAR-related signaling pathways.
Chronic exposure produced significantly higher hippocampal enzyme levels than acute exposure at both 900 and 2100 MHz.
Enzyme levels were significantly higher at 2100 MHz than at 900 MHz in both acute and chronic exposure groups.
The authors concluded that both exposure duration and carrier frequency had different effects on hippocampal protein expression in Wistar rats, which might encourage further research on protection against RF-EMR exposure.