Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.
50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1G93A model of amyotrophic lateral sclerosis.
Consales C, Panatta M, Butera A, Filomeni G, Merla C, Carrì MT, Marino C, Benassi B · 2018
View Original AbstractPower frequency magnetic fields disrupted iron metabolism genes in ALS-susceptible cells, suggesting genetic vulnerability may amplify EMF health risks.
Plain English Summary
Researchers exposed lab-grown nerve cells with ALS-related genetic mutations to 50 Hz magnetic fields (the same frequency as power lines) for up to 72 hours. They found that while the magnetic field didn't kill cells or increase oxidative stress, it disrupted iron metabolism genes specifically in cells with the SOD1G93A mutation linked to familial ALS. This suggests that power frequency magnetic fields may interfere with cellular iron regulation in genetically susceptible individuals.
Study Details
We characterized the response to the extremely low frequency magnetic field (ELF-MF) in an in vitro model of familial Amyotrophic Lateral Sclerosis (fALS), carrying two mutant variants of the superoxide dismutase 1 (SOD1) gene.
SH-SY5Y human neuroblastoma cells, stably over-expressing the wild type, the G93A or the H46R mutant...
We report that 50-Hz MF exposure induces: (i) no change in proliferation and viability; (ii) no modu...
50-Hz MF affects iron homeostasis in the in vitro SOD1G93A ALS model.
Show BibTeX
@article{c_2018_50hz_magnetic_field_impairs_2838,
author = {Consales C and Panatta M and Butera A and Filomeni G and Merla C and Carrì MT and Marino C and Benassi B},
title = {50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1G93A model of amyotrophic lateral sclerosis.},
year = {2018},
doi = {10.1080/09553002.2019.1552378},
url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2019.1552378},
}