Immunohistochemical localization of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in the superior olivary complex of mice after radiofrequency exposure
Maskey D, Kim MJ · 2014
View Original AbstractRadiofrequency exposure at a specific absorption rate of 1.6 W/kg was associated with significant decreases in BDNF and GDNF levels in auditory brain nuclei of mice.
Plain English Summary
Researchers applied radiofrequency at a specific absorption rate of 1.6 W/kg or 0 W/kg to mice to study the distribution of BDNF and GDNF in the nuclei of the superior olivary complex. In the exposed group, significant reductions in BDNF immunoreactivity were noted in the lateral superior olive, medial superior olive, superior paraolivary nucleus, and medial nucleus of the trapezoid body. GDNF immunoreactivity was also significantly decreased (p < 0.001) in all superior olivary complex nuclei of the exposed group. The researchers suggested that the decrease in these neurotrophic factors in the superior olivary complex suggests a detrimental effect of RF exposure in the auditory nuclei.
Why This Matters
The study compared mice in the 1.6 W/kg group against a control group receiving 0 W/kg, measuring BDNF and GDNF in auditory brain regions. Both neurotrophic factors showed significant reductions in the exposed mice, with GDNF reaching a significance level of p < 0.001 across all measured nuclei. The researchers interpreted these findings as suggesting a detrimental effect of RF exposure in the auditory nuclei.
Exposure Details
- SAR
- 1.6 or 0 W/kg
- Source/Device
- 835 MHz
- Exposure Duration
- continuous for 8 h/day for 3 months
Exposure Context
This study used 1.6 or 0 W/kg for SAR (device absorption):
- 4x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The present study applied radiofrequency at a specific absorption rate (SAR) of 1.6 W/kg (E1.6) or 0 W/kg group to determine the distribution of BDNF and GDNF in the nuclei of superior olivary complex (SOC).
In the E1.6 group, significant decrements of BDNF immunoreactivity (IR) were noted in the lateral su...
Show BibTeX
@article{d_2014_immunohistochemical_localization_of_brainderived_140,
author = {Maskey D and Kim MJ},
title = {Immunohistochemical localization of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in the superior olivary complex of mice after radiofrequency exposure},
year = {2014},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394014001086},
}