The action of pulse‐modulated GSM radiation increases regional changes in brain activity and c‐Fos expression in cortical and subcortical areas in a rat model of picrotoxin‐induced seizure proneness
López-Martín E, Bregains J, Relova-Quinteiro JL, Cadarso-Suárez C, Jorge-Barreiro FJ, Ares-Pena FJ. · 2009
View Original AbstractPulse-modulated GSM radiation produced different brain activity and c-Fos expression patterns in seizure-prone rats compared with unmodulated radiation of the same wavelength.
Plain English Summary
Researchers studied whether pulse-modulated GSM radiation had different effects on brain activity than an unmodulated signal of the same wavelength, and examined c-Fos expression in seizure-related brain circuits. Rats made seizure-prone with picrotoxin and then exposed to GSM radiation showed differences in clinical and EEG signs and in c-Fos expression compared with picrotoxin-treated rats exposed to unmodulated radiation. The most marked effects of GSM radiation on c-Fos expression in picrotoxin-treated rats were observed in limbic structures, olfactory cortex areas, subcortical areas, the dentate gyrus, and the central lateral nucleus of the thalamic intralaminar nucleus group. Neither radiation treatment caused tissue heating, so the researchers ruled out thermal effects.
Why This Matters
Animals not treated with picrotoxin but exposed to unmodulated radiation showed the highest c-Fos expression in cortical areas, a different pattern from the seizure-prone animals. The researchers suggested that this mobile-phone-type radiation might induce regional changes in previous preexcitability conditions of neuronal activation.
Exposure Details
- SAR
- 0.26,0.3,1.4 W/kg
- Source/Device
- 900 MHz
- Exposure Duration
- continuous for 2 hr
Where This Falls on the Concern Scale
Study Details
To assess whether the effects on brain activity of pulse modulated GSM differ from those of a non-modulated signal of the same wavelength and if so to study c-Fos expression in seizure-related anatomical circuits.
In the present study, GSM‐exposed picrotoxin‐pretreated rats showed differences in clinical and EEG...
These results suggest a specific effect of the pulse modulation of GSM radiation on brain activity of a picrotoxin‐induced seizure‐proneness rat model and indicate that this mobile‐phone‐type radiation might induce regional changes in previous preexcitability conditions of neuronal activation.
Show BibTeX
@article{e_2009_the_action_of_pulsemodulated_128,
author = {López-Martín E and Bregains J and Relova-Quinteiro JL and Cadarso-Suárez C and Jorge-Barreiro FJ and Ares-Pena FJ. },
title = {The action of pulse‐modulated GSM radiation increases regional changes in brain activity and c‐Fos expression in cortical and subcortical areas in a rat model of picrotoxin‐induced seizure proneness},
year = {2009},
doi = {10.1002/jnr.21951},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.21951},
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