Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate.

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Ozgur E, Güler G, Seyhan N. · 2010

Exposure to mobile phone-like radiation increased oxidative stress markers in guinea pig livers, and antioxidants NAC and EGCG helped protect against this damage.

Plain English Summary

Summary written for general audiences

Researchers exposed guinea pigs to an 1800-MHz GSM-modulated signal at a whole body SAR of 0.38 W/kg for 10 or 20 minutes per day for seven days to study oxidative damage in the liver. After exposure, significant increases in malondialdehyde and total nitric oxide levels were observed, along with decreases in several antioxidant enzyme activities in the liver. The extent of oxidative damage was found to be proportional to the duration of exposure, and both NAC and EGCG were found to protect liver tissue against this damage.

Why This Matters

Nine groups of guinea pigs were used to compare different exposure durations and antioxidant treatments. Only NAC treatment increased hepatic GSH-Px activities, whereas EGCG treatment alone attenuated MDA level. The researchers suggested that the adverse effect of the radiation may be related to the duration of mobile phone use.

Exposure Details

SAR: 0.38 W/kg
Source/Device: 1800-MHz
Exposure Duration: 10 or 20 min per day for seven days

Where This Falls on the Concern Scale

Study Details

To investigate oxidative damage and antioxidant enzyme status in the liver of guinea pigs exposed to mobile phone-like radiofrequency radiation (RFR) and the potential protective effects of N-acetyl cysteine (NAC) and epigallocatechin-gallate (EGCG) on the oxidative damage.

Nine groups of guinea pigs were used to study the effects of exposure to an 1800-MHz Global System f...

Significant increases in malondialdehyde (MDA) and total nitric oxide (NO(x)) levels and decreases i...

Mobile phone-like radiation induces oxidative damage and changes the activities of antioxidant enzymes in the liver. The adverse effect of RFR may be related to the duration of mobile phone use. NAC and EGCG protect the liver tissue against the RFR-induced oxidative damage and enhance antioxidant enzyme activities.

Cite This Study

Ozgur E, Güler G, Seyhan N. (2010). Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate. Int J Radiat Biol. 86(1):935-945, 2010.

Show BibTeX

@article{e_2010_mobile_phone_radiationinduced_free_562,
  author = {Ozgur E and Güler G and Seyhan N.},
  title = {Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate.},
  year = {2010},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/20807176/},
}

PubMed: 20807176