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The Effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on Liver Tissue Protein Oxidation and Antioxidant Enzyme Levels After the Exposure to Radio Frequency Radiation.

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Ozgur E, Sahin D, Tomruk A, Guler G, Sepici-Dinçel A, Altan N, Seyhan N. · 2014

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SOD activity significantly decreased in guinea pig liver after radio frequency radiation exposure, while protein damage did not change.

Plain English Summary

Summary written for general audiences

Researchers exposed adult male guinea pigs to GSM-modulated radio frequency radiation at an average whole body SAR of 0.4 W/kg for 10 or 20 minutes daily for seven consecutive days. The study measured protein oxidation, advanced oxidation protein products, and superoxide dismutase activity in liver tissue, and also tested NAC and EGCG as potential protective treatments. SOD activity significantly decreased after radio frequency radiation exposure, but protein damage did not change. NAC treatment alone increased PCO levels, and EGCG treatment alone elevated AOPP levels.

Why This Matters

Adult male guinea pigs were randomly divided into nine groups covering sham exposure and radio frequency radiation exposure combined with saline, EGCG, or NAC treatments. The study aimed to investigate effects of radio frequency radiation on guinea pig liver tissue and the protective effects of antioxidant treatments. The researchers noted that antioxidants showed pro-oxidant behavior, and concluded that well decided doses and treatment timetables of NAC and EGCG are needed.

Exposure Details

SAR
0.4 W/kg
Source/Device
900 MHz
Exposure Duration
10 or 20 min daily for consecutive 7 days

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.4 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 4 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of this experimental study was to investigate the effect of 900 MHz Global System for Mobile Communications (GSM)-modulated RFR (average whole body Specific Absorption Rate (SAR) of 0.4 W/kg, 10 or 20 min daily for consecutive 7 days) to the liver tissue of guinea pigs and the protective effects of antioxidant treatments.

Adult male guinea pigs were randomly divided into nine groups as: Group I (sham/saline), Group II (s...

Significant decreases in the activities of SOD were observed in the liver of guinea pigs after RFR e...

Due to antioxidants having pro-oxidant behavior, the well decided doses and treatment timetables of NAC and ECGC are needed.

Cite This Study
Ozgur E, Sahin D, Tomruk A, Guler G, Sepici-Dinçel A, Altan N, Seyhan N. (2014). The Effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on Liver Tissue Protein Oxidation and Antioxidant Enzyme Levels After the Exposure to Radio Frequency Radiation. Int J Radiat Biol. 2014 Sep 24:1-19.
Show BibTeX
@article{e_2014_the_effects_of_nacetyllcysteine_563,
  author = {Ozgur E and Sahin D and Tomruk A and Guler G and Sepici-Dinçel A and Altan N and Seyhan N.},
  title = {The Effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on Liver Tissue Protein Oxidation and Antioxidant Enzyme Levels After the Exposure to Radio Frequency Radiation.},
  year = {2014},
  doi = {10.3109/09553002.2015.966210},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2015.966210},
}
DOI: 10.3109/09553002.2015.966210

Cited By (9 papers)

Quick Questions About This Study

Guinea pigs were exposed to GSM-modulated radio frequency radiation at an average whole body SAR of 0.4 W/kg for 10 or 20 minutes daily for seven consecutive days.
Significant decreases in SOD activity were observed in the liver of guinea pigs after radio frequency radiation exposure.
Protein damage did not change due to radio frequency radiation exposure.
NAC treatment alone increased PCO levels and EGCG treatment alone elevated AOPP levels.
The researchers stated that, due to antioxidants having pro-oxidant behavior, well decided doses and treatment timetables of NAC and EGCG are needed.