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Oxidative Stress233 citations

Oxidative Damage in the Kidney Induced by 900-MHz-Emitted Mobile Phone: Protection by Melatonin

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Oktem F, Ozguner F, Mollaoglu H, Koyu A, Uz E. · 2005

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Rats exposed to 900-MHz mobile phone radiation showed increased kidney oxidative stress markers, which melatonin treatment reversed.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to 900-MHz mobile phone radiation for 30 minutes daily over 10 days. Exposure increased kidney tissue malondialdehyde and urine N-acetyl-beta-d-glucosaminidase while decreasing superoxide dismutase, catalase, and glutathione peroxidase activities. Melatonin administered before each exposure reversed these changes. The authors concluded that melatonin may protect against mobile phone-induced kidney impairment in rats.

Why This Matters

The study also measured superoxide dismutase, catalase, and glutathione peroxidase activities to assess antioxidant status. The authors interpreted the increased oxidative stress markers and decreased antioxidant enzymes as evidence of an oxidative mechanism from the radiation exposure, and that melatonin ameliorated the injury via its antioxidant properties.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 MHz Duration: 30 min/day for 10 days

Study Details

The aim of this study was to examine 900-MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) on renal tubular damage and the role of melatonin on kidney tissue against possible oxidative damage in rats.

The animals were randomly grouped as follows: 1) sham-operated control group and 2) study groups: i)...

In the EMR-exposed group, while tissue MDA and urine NAG levels increased, SOD, CAT, and GSH-Px acti...

These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment in rats.

Cite This Study
Oktem F, Ozguner F, Mollaoglu H, Koyu A, Uz E. (2005). Oxidative Damage in the Kidney Induced by 900-MHz-Emitted Mobile Phone: Protection by Melatonin Arch Med Res. 36(4):350-355, 2005.
Show BibTeX
@article{f_2005_oxidative_damage_in_the_1683,
  author = {Oktem F and Ozguner F and Mollaoglu H and Koyu A and Uz E.},
  title = {Oxidative Damage in the Kidney Induced by 900-MHz-Emitted Mobile Phone: Protection by Melatonin},
  year = {2005},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/15950073/},
}
PubMed: 15950073

Cited By (233 papers)

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Quick Questions About This Study

Rats were exposed to 900-MHz electromagnetic radiation for 30 minutes per day over 10 days.
Exposure increased tissue malondialdehyde and urine N-acetyl-beta-d-glucosaminidase levels while decreasing superoxide dismutase, catalase, and glutathione peroxidase activities.
Melatonin given before each exposure reversed the increases in malondialdehyde and NAG and the decreases in superoxide dismutase, catalase, and glutathione peroxidase.
The researchers concluded that melatonin may exhibit a protective effect on mobile phone-induced renal impairment in rats.
Malondialdehyde was used as an index of lipid peroxidation, urine N-acetyl-beta-d-glucosaminidase as a marker of renal tubular damage, and superoxide dismutase, catalase, and glutathione peroxidase activities to evaluate antioxidant status.