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Oxidative Stress

Effect of exposure to the edge signal on oxidative stress in brain cell models.

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Poulletier de Gannes F, Haro E, Hurtier A, Taxile M, Ruffié G, Billaudel B, Veyret B, Lagroye I. · 2011

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Exposure to the EDGE signal did not induce oxidative stress in human brain cell models at up to 10 W/kg.

Plain English Summary

Summary written for general audiences

Researchers exposed three human brain cell lines and primary cortical neurons to the EDGE signal at 1800 MHz. Four exposure conditions were tested: 2 and 10 W/kg for 1 and 24 hours. Reactive oxygen species production was measured by flow cytometry using the DCFH-DA probe. All cells tested responded to rotenone treatment by increasing ROS production. The EDGE signal did not induce oxidative stress under any test condition, including at 10 W/kg.

Why This Matters

Rotenone treatment served as a positive control in the experiment. The authors noted that their results agree with earlier findings that RF radiation alone does not increase ROS production.

Exposure Details

SAR
2 and 10 W/kg

Exposure Context

This study used 2 and 10 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2 and 10 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit

Study Details

In this study we investigated the effect of the Enhanced Data rate for GSM Evolution (EDGE) signal on cells of three human brain cell lines, SH-SY5Y, U87 and CHME5, used as models of neurons, astrocytes and microglia, respectively, as well as on primary cortical neuron cultures.

SXC-1800 waveguides (IT'IS-Foundation, Zürich, Switzerland) were modified for in vitro exposure to t...

All cells tested responded to rotenone treatment by increasing ROS production.

These findings indicate that exposure to the EDGE signal does not induce oxidative stress under these test conditions, including 10 W/kg. Our results are in agreement with earlier findings that RF radiation alone does not increase ROS production.

Cite This Study
Poulletier de Gannes F, Haro E, Hurtier A, Taxile M, Ruffié G, Billaudel B, Veyret B, Lagroye I. (2011). Effect of exposure to the edge signal on oxidative stress in brain cell models. Radiat Res. 175(2):225-230, 2011.
Show BibTeX
@article{f_2011_effect_of_exposure_to_1274,
  author = {Poulletier de Gannes F and Haro E and Hurtier A and Taxile M and Ruffié G and Billaudel B and Veyret B and Lagroye I.},
  title = {Effect of exposure to the edge signal on oxidative stress in brain cell models.},
  year = {2011},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/21268716/},
}
PubMed: 21268716

Cited By (27 papers)

Quick Questions About This Study

The study used three human brain cell lines (SH-SY5Y, U87, CHME5) and primary cortical neuron cultures.
Four exposure conditions were tested: 2 and 10 W/kg for 1 and 24 hours.
Reactive oxygen species production was measured by flow cytometry using the DCFH-DA probe.
Exposure to the EDGE signal did not induce oxidative stress under the test conditions, including at 10 W/kg.
Rotenone treatment was used as a positive control and increased ROS production in all cell types.