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Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway.

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Feng B, Qiu L, Ye C, Chen L, Fu Y, Sun W. · 2016

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Exposure to a 50-Hz magnetic field transiently induced mitochondrial permeability transition in human amniotic epithelial cells through the ROS/GSK-3β signaling pathway.

Plain English Summary

Summary written for general audiences

Researchers exposed human amniotic epithelial cells to a 50-Hz magnetic field at 0.4 mT and examined mitochondrial permeability, mitochondrial membrane potential, and cytochrome c release. Exposure to the magnetic field at 0.4 mT for 60 min transiently induced mitochondrial permeability transition and Cyt-c release, although there was no significant effect on mitochondrial membrane potential. Cells exposed to the magnetic field showed increased intracellular reactive oxidative species levels and GSK-3β dephosphorylation, and the induced mitochondrial permeability transition was attenuated by a ROS scavenger or GSK-3β inhibitor.

Why This Matters

Mitochondrial permeability transition and Cyt-c release were transiently induced after exposure at 0.4 mT for 60 min, but mitochondrial membrane potential was not significantly affected. Other than decreasing the total Bax level, magnetic field exposure did not significantly affect the levels of Bax and Bcl-2 in mitochondria. Pretreatment with the ROS scavenger NAC prevented the GSK-3β dephosphorylation caused by magnetic field exposure, supporting a role for ROS upstream of GSK-3β in this pathway.

Exposure Details

Magnetic Field
0.4 mT
Source/Device
50 Hz
Exposure Duration
60 min

Exposure Context

This study used 0.4 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.4 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 2 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

To investigate the biological effects of a 50-Hz magnetic field (MF) on mitochondrial permeability.

Human amniotic epithelial cells were exposed to MF (50 Hz, 0.4 mT) for different durations. Mitochon...

Exposure to the MF at 0.4 mT for 60 min transiently induced mitochondrial permeability transition (M...

MPT induced by MF exposure was mediated through the ROS/GSK-3β signaling pathway.

Cite This Study
Feng B, Qiu L, Ye C, Chen L, Fu Y, Sun W. (2016). Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway. Int J Radiat Biol. 92:148-155, 2016a.
Show BibTeX
@article{b_2016_exposure_to_a_50hz_359,
  author = {Feng B and Qiu L and Ye C and Chen L and Fu Y and Sun W.},
  title = {Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway.},
  year = {2016},
  doi = {10.3109/09553002.2016.1135261},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2016.1135261},
}
DOI: 10.3109/09553002.2016.1135261

Cited By (26 papers)

Quick Questions About This Study

Human amniotic epithelial cells were used and exposed to a 50-Hz magnetic field at 0.4 mT for different durations.
There was no significant effect on mitochondrial membrane potential after exposure to the magnetic field at 0.4 mT for 60 min.
Mitochondrial permeability transition induced by magnetic field exposure was mediated through the ROS/GSK-3β signaling pathway.
The magnetic field-induced mitochondrial permeability transition was attenuated by the ROS scavenger NAC, and NAC pretreatment also prevented GSK-3β dephosphorylation caused by the magnetic field.
Magnetic field exposure did not significantly affect the levels of Bax and Bcl-2 in mitochondria, other than decreasing total Bax levels.