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Histopathological, immunohistochemical, and stereological analysis of the effect of Gingko biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation.

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Gevrek F. · 2017

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Rats exposed to cellphone EMR for one month showed signs of reduced hippocampal cell viability, while Ginkgo biloba (Egb761) treatment appeared to partially counteract those effects.

Plain English Summary

Summary written for general audiences

Rats were divided into three groups — Control, EMR, and EMR+Egb761 — and the EMR groups were exposed to cellphone radiation at 0.96 W/kg SAR for one month. In the EMR group, apoptotic proteins (Bax, Acas-3) increased and the anti-apoptotic protein Bcl-2 decreased, along with a reduction in total granule and pyramidal cell counts. Rats that also received Egb761 showed decreased Bax and Acas-3, increased Bcl-2, fewer TUNEL-stained apoptotic cells, and a higher total viable cell number.

Why This Matters

The study used stereological, TUNEL-staining, and immunohistochemical methods to assess hippocampal changes in exposed rats. The researchers noted that the hippocampus was of particular interest because of its close proximity to radiation during cellphone use. The authors concluded that chronic cellphone EMR exposure may affect hippocampal cell viability, and that Egb761 may be used to mitigate some of the deleterious effects.

Exposure Details

SAR
0.96 W/kg
Exposure Duration
One month

Exposure Context

This study used 0.96 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.96 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level

Study Details

The effects of cellphone EMR exposure on the hippocampus of rats and the possible counteractive effects of Ginkgo biloba (Egb761) were aimed to investigate.

Rats were divided into three groups: Control, EMR, and EMR+Egb761. The EMR and EMR+Egb761 groups wer...

An increase in apoptotic proteins (Bax, Acas-3) and a decrease in anti-apoptotic protein (Bcl-2) imm...

In conclusion, chronic cellphone EMR exposure may affect hippocampal cell viability, and Egb761 may be used to mitigate some of the deleterious effects.

Cite This Study
Gevrek F. (2017). Histopathological, immunohistochemical, and stereological analysis of the effect of Gingko biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation. Histol Histopathol. 2017 Nov 9:11943.
Show BibTeX
@article{f._2017_histopathological_immunohistochemical_and_stereological_999,
  author = {Gevrek F.},
  title = {Histopathological, immunohistochemical, and stereological analysis of the effect of Gingko biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/29120031/},
}
PubMed: 29120031

Cited By (8 papers)

Quick Questions About This Study

The EMR groups were exposed to cellphone radiation at 0.96 W/kg SAR for one month.
Apoptotic proteins increased, the anti-apoptotic protein Bcl-2 decreased, and total granule and pyramidal cell counts declined in the EMR group.
Rats treated with Egb761 showed a decrease in Bax and Acas-3, an increase in Bcl-2, fewer TUNEL-stained apoptotic cells, and a higher total viable cell number.
The researchers concluded that Egb761 may be used to mitigate some of the deleterious effects of chronic cellphone EMR exposure.