Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis
Medina-Fernandez FJ, Escribano BM, Luque E, Caballero-Villarraso J, Gomez-Chaparro JL, Feijoo M, Garcia-Maceira FI, Pascual-Leone A, Drucker-Colin R, Tunez I · 2018
View Original AbstractTranscranial magnetic stimulation reduced oxidative stress and clinical scores in rats with an experimental autoimmune encephalomyelitis model, more significantly than natalizumab, dimethyl fumarate, or dexamethasone.
Plain English Summary
Researchers studied the effects of transcranial magnetic stimulation (TMS), natalizumab, dimethyl fumarate, and dexamethasone on Dark Agouti rats given a single dose of myelin oligodendrocyte glycoprotein (MOG). MOG triggered a significant increase in clinical score and in levels of lipid peroxides and carbonylated proteins, but reduced the GSH/GSSG ratio in brain, spinal cord and blood. Both TMS and the clinical treatments decreased the changes caused by MOG, with TMS doing so more significantly.
Why This Matters
TMS was applied at 60 Hz and 0.7 mT, while natalizumab was given at 5 mg/kg, dimethyl fumarate at 15 mg/kg, and dexamethasone at 300 μg/kg. The researchers measured clinical score, lipid peroxides, carbonylated proteins, and the ratio of reduced to oxidized glutathione in brain, spinal cord, and blood. The results were described by the researchers as supporting an antioxidant and neuroprotective action of TMS, and an activity higher than the other clinical treatments tested.
Exposure Details
- Magnetic Field
- 0.7 mT
- Source/Device
- 60 Hz
Exposure Context
This study used 0.7 mT for magnetic fields:
- 35Kx above the Building Biology guideline of 0.2 mG
- 7Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied.
TMS (60 Hz and 0.7 mT), nata (5 mg/kg), DMF (15 mg/kg) and DEX (300 μg/kg) was applied for 21 after ...
MOG triggered significant increase in clinical score and in the levels of lipid peroxides and carbon...
These results support the antioxidant and neuroprotective action of TMS, as well as an activity higher than other clinical treatments.
Show BibTeX
@article{fj_2018_comparative_of_transcranial_magnetic_426,
author = {Medina-Fernandez FJ and Escribano BM and Luque E and Caballero-Villarraso J and Gomez-Chaparro JL and Feijoo M and Garcia-Maceira FI and Pascual-Leone A and Drucker-Colin R and Tunez I},
title = {Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis},
year = {2018},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0361923017305786},
}