Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells.
Del Vecchio G, Giuliani A, Fernandez M, Mesirca P, Bersani F, Pinto R, Ardoino L, Lovisolo GA, Giardino L, Calzà L · 2009
View Original AbstractExposure to 900 MHz GSM-modulated RF-EMF reduced the number of neurites in both a cholinergic cell line and rat primary cortical neurons.
Plain English Summary
Researchers studied the effects of radiofrequency electromagnetic field exposure on neuronal maturation using two in vitro models: murine SN56 cholinergic cells and rat primary cortical neurons. Cells were exposed at 1 W/kg at 900 MHz GSM modulated, and neurite emission, outgrowth, and branching were examined at multiple time points. RF-EMF exposure reduced the number of neurites in both cell systems, and this reduction correlated with increased expression of beta-thymosin mRNA.
Why This Matters
The study used two separate cell systems: a murine cholinergic cell line (SN56) and rat primary cortical neurons, allowing researchers to check whether the effect appeared in more than one model. Morphological analysis covered neurite emission, outgrowth, and branching, observed on live and immunolabeled neurons at several time points during exposure. Cortical neurons were also tested for changes in cytoskeleton-regulating factors such as beta-thymosin, and early genes such as c-Fos and c-Jun, measured by real-time PCR after 24 hours of EMF exposure.
Exposure Details
- SAR
- 1 W/kg
- Source/Device
- 900 MHz GSM
- Exposure Duration
- 48 and 72 h (24 and 48 h of SN56 cell line differentiation) or at 24, 72, 120 h (2, 4 and 6 days in vitro for cortical neurons)
Exposure Context
This study used 1 W/kg for SAR (device absorption):
- 2.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The effects of radiofrequency electromagnetic field (RF-EMF) exposure on neuronal phenotype maturation have been studied in two different in vitro models: murine SN56 cholinergic cell line and rat primary cortical neurons.
The samples were exposed at a dose of 1 W/kg at 900 MHz GSM modulated. The phenotype analysis was ca...
We found that RF-EMF exposure reduced the number of neurites generated by both cell systems, and thi...
Show BibTeX
@article{g_2009_continuous_exposure_to_900mhz_13,
author = {Del Vecchio G and Giuliani A and Fernandez M and Mesirca P and Bersani F and Pinto R and Ardoino L and Lovisolo GA and Giardino L and Calzà L},
title = {Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells.},
year = {2009},
url = {http://www.sciencedirect.com/science/article/pii/S0304394009003632},
}