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Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone.

Bioeffects Seen

Nittby H, Brun A, Eberhardt J, Malmgren L, Persson BR, Salford LG · 2009

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Albumin extravasation was enhanced in mobile phone exposed rats compared to sham controls after a 7-day recovery period.

Plain English Summary

Summary written for general audiences

Rats were exposed in TEM-cells for 2 hours at non-thermal specific absorption rates of 0, 0.12, 1.2, 12, and 120 mW/kg, and albumin extravasation over the blood-brain barrier, neuronal albumin uptake, and neuronal damage were assessed. Albumin extravasation was enhanced in the mobile phone exposed rats compared to sham controls after a 7-day recovery period, with a significant result at the SAR value of 12 mW/kg. There was a low but significant correlation between the exposure level and the occurrence of focal albumin extravasation.

Why This Matters

A trend of increased albumin extravasation was also seen at SAR values of 0.12 mW/kg and 120 mW/kg, in addition to the significant result at 12 mW/kg. The authors noted that these findings agreed with their earlier studies showing increased blood-brain barrier permeability immediately and 14 days after exposure.

Exposure Details

SAR
0, 0.00012, 0.0012, 0.012, 0.12 W/kg
Source/Device
915 MHz
Exposure Duration
2 h

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0, 0.00012, 0.0012, 0.012, 0.12 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects documented below the Building Biology "No Concern" threshold (0.001 W/kg)FCC limit is 13,333 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 915 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 915 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

In the background section of this report, we present a thorough review of the literature on the demonstrated effects (or lack of effects) of microwave exposure upon the BBB.

Furthermore, we have continued our own studies by investigating the effects of GSM mobile phone radi...

Albumin extravasation was enhanced in the mobile phone exposed rats as compared to sham controls aft...

The present findings are in agreement with our earlier studies where we have seen increased BBB permeability immediately and 14 days after exposure. We here discuss the present findings as well as the previous results of altered BBB permeability from our and other laboratories.

Cite This Study
Nittby H, Brun A, Eberhardt J, Malmgren L, Persson BR, Salford LG (2009). Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone. Pathophysiology. 16(2-3):103-112, 2009.
Show BibTeX
@article{h_2009_increased_bloodbrain_barrier_permeability_159,
  author = {Nittby H and Brun A and Eberhardt J and Malmgren L and Persson BR and Salford LG},
  title = {Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone.},
  year = {2009},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0928468009000133},
}

Quick Questions About This Study

Rats were exposed in TEM-cells for 2 hours at non-thermal specific absorption rates of 0, 0.12, 1.2, 12, and 120 mW/kg.
Albumin extravasation was enhanced in exposed rats compared to sham controls after the 7-day recovery period, with a significant result at 12 mW/kg.
There was a low but significant correlation between the exposure level and the occurrence of focal albumin extravasation.
The study assessed albumin extravasation over the blood-brain barrier, neuronal albumin uptake, and neuronal damage.
The authors reported that the findings agreed with their earlier studies showing increased blood-brain barrier permeability immediately and 14 days after exposure.