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Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation.

Bioeffects Seen

Belyaev IY, Koch CB, Terenius O, Roxstrom-Lindquist K, Malmgren LO, H Sommer W, Salford LG, Persson BR. · 2006

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Cell phone radiation altered brain gene expression in just 2 hours at exposure levels considered safe by current standards.

Plain English Summary

Summary written for general audiences

Scientists exposed rats to cell phone radiation at 915 MHz for 2 hours and found it changed gene activity in the brain without causing DNA breaks. The radiation altered the expression of 12 genes involved in brain functions like neurotransmitter regulation, the blood-brain barrier, and melatonin production. This suggests that even brief cell phone exposure can trigger biological changes in brain cells, even when DNA damage isn't detectable.

Why This Matters

This study reveals something crucial that the wireless industry doesn't want you to know: your brain responds to cell phone radiation even when there's no obvious DNA damage. The researchers found that just 2 hours of exposure at 0.4 mW/g SAR (well below current safety limits) was enough to alter gene expression in rat brains. What makes this particularly significant is that the affected genes control critical brain functions including the blood-brain barrier, which protects your brain from toxins, and melatonin production, which regulates your sleep cycle. The science demonstrates that biological effects occur at exposure levels far below what regulators consider 'safe.' You don't have to wait for DNA breaks to be concerned about what cell phone radiation is doing to your brain.

Exposure Details

SAR
0.4 W/kg
Source/Device
915 MHz
Exposure Duration
2 hours

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.4 W/kgExtreme Concern0.1 W/kgFCC Limit1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 4x higher than this exposure level

Study Details

We investigated whether exposure of rat brain to microwaves (MWs) of global system for mobile communication (GSM) induces DNA breaks, changes in chromatin conformation and in gene expression.

An exposure installation was used based on a test mobile phone employing a GSM signal at 915 MHz, al...

In cerebellum from all exposed animals, 11 genes were upregulated in a range of 1.34-2.74 fold and o...

The data shows that GSM MWs at 915 MHz did not induce PFGE-detectable DNA double stranded breaks or changes in chromatin conformation, but affected expression of genes in rat brain cells.

Cite This Study
Belyaev IY, Koch CB, Terenius O, Roxstrom-Lindquist K, Malmgren LO, H Sommer W, Salford LG, Persson BR. (2006). Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation. Bioelectromagnetics.27(4):295-306,2006.
Show BibTeX
@article{iy_2006_exposure_of_rat_brain_855,
  author = {Belyaev IY and Koch CB and Terenius O and Roxstrom-Lindquist K and Malmgren LO and H Sommer W and Salford LG and Persson BR.},
  title = {Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation.},
  year = {2006},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/16511873/},
}

Quick Questions About This Study

Scientists exposed rats to cell phone radiation at 915 MHz for 2 hours and found it changed gene activity in the brain without causing DNA breaks. The radiation altered the expression of 12 genes involved in brain functions like neurotransmitter regulation, the blood-brain barrier, and melatonin production. This suggests that even brief cell phone exposure can trigger biological changes in brain cells, even when DNA damage isn't detectable.