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The relationship between NMDA receptors and microwave-induced learning and memory impairment: A long-term observation on Wistar rats.

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Wang H, Peng R, Zhao L, Wang S, Gao Y, Wang L, Zuo H, Dong J, Xu X, Zhou H, Su Z · 2014

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Six minutes of microwave exposure caused learning and memory problems lasting 18 months in rats, suggesting persistent cognitive damage from brief wireless radiation exposure.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to microwave radiation at 2.856 GHz for six minutes and monitored them for 18 months. The rats developed persistent learning and memory problems plus brain damage in memory centers, suggesting brief microwave exposure can cause lasting cognitive harm.

Why This Matters

This study delivers sobering evidence that microwave radiation can cause persistent cognitive damage that lasts well beyond the exposure period. The researchers used a frequency of 2.856 GHz, which falls within the range of common wireless technologies like WiFi and Bluetooth. What makes this research particularly concerning is the duration of effects - rats showed learning and memory problems for the entire 18-month observation period after just 6 minutes of exposure at 50 mW/cm² power density.

The science demonstrates multiple pathways of harm: damaged brain tissue structure, disrupted neurotransmitter balance, and altered receptor expression in the hippocampus. This isn't just one isolated effect but a cascade of neurological changes that persisted long after exposure ended. While we can't directly extrapolate from rat studies to humans, this research adds to a growing body of evidence suggesting that microwave radiation may have lasting impacts on cognitive function - effects that warrant serious consideration given our increasing exposure to these frequencies in daily life.

Exposure Details

Power Density
0, 50 µW/m²
Source/Device
2.856 GHz
Exposure Duration
6 min

Exposure Context

This study used 0, 50 µW/m² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0, 50 µW/m²Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the Severe Concern range (Building Biology)FCC limit is 200,000x higher than this exposure level

Study Details

To investigate whether high power microwave could cause continuous disorders to learning and memory in Wistar rats and to explore the underlying mechanisms.

Eighty Wistar rats were exposed to a 2.856 GHz pulsed microwave source at a power density of 0 mW/cm...

Our results showed that the microwave-exposed rats showed consistent deficiencies in spatial learnin...

This study indicated that the content of amino acids neurotransmitters, the expression of NMDAR subunits and the variation of hippocampal structure might contribute to the long-term cognitive impairment after microwave exposure.

Cite This Study
Wang H, Peng R, Zhao L, Wang S, Gao Y, Wang L, Zuo H, Dong J, Xu X, Zhou H, Su Z (2014). The relationship between NMDA receptors and microwave-induced learning and memory impairment: A long-term observation on Wistar rats. Int J Radiat Biol. 2014 Nov 26:1-25.
Show BibTeX
@article{h_2014_the_relationship_between_nmda_198,
  author = {Wang H and Peng R and Zhao L and Wang S and Gao Y and Wang L and Zuo H and Dong J and Xu X and Zhou H and Su Z},
  title = {The relationship between NMDA receptors and microwave-induced learning and memory impairment: A long-term observation on Wistar rats.},
  year = {2014},
  doi = {10.3109/09553002.2014.988893},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2014.988893},
}

Quick Questions About This Study

Researchers exposed rats to microwave radiation at 2.856 GHz for six minutes and monitored them for 18 months. The rats developed persistent learning and memory problems plus brain damage in memory centers, suggesting brief microwave exposure can cause lasting cognitive harm.