Circadian Rhythmicity of Antioxidant Markers in Rats Exposed to 1.8 GHz Radiofrequency Fields
Cao H, Qin F, Liu X, Wang J, Cao Y, Tong J, Zhao H · 2015
View Original AbstractCircadian rhythms of antioxidant markers in rats were shifted after 1.8 GHz radiofrequency exposure, with levels significantly decreased when exposure was given at 23 and 3 h GMT.
Plain English Summary
Researchers exposed male Sprague Dawley rats to 1.8 GHz radiofrequency fields at different times of day to study whether circadian rhythms of plasma antioxidants were affected. Six groups of animals were exposed at a power density of 201.7 μW/cm2 and a specific absorption rate of 0.05653 W/kg for 2 hours per day for 32 consecutive days, each at a different time of day, while a seventh group served as sham-exposed controls. The circadian rhythms of melatonin, GSH-Px, and SOD were shifted in exposed rats, with levels significantly decreased when exposure was given at 23 and 3 h GMT. The researchers concluded that there may be adverse effects of radiofrequency exposure on antioxidant function, affecting both daily antioxidant levels and circadian rhythmicity.
Why This Matters
The study used seven groups of male Sprague Dawley rats, with six exposed to 1.8 GHz radiofrequency fields at six different times of day and one sham group. After the final exposure, blood was collected every 4 hours over a full 24-hour period from both exposed and sham animals. The three antioxidants measured were melatonin, GSH-Px, and SOD, and data from exposed rats were compared with those from sham-exposed animals. Levels of all three antioxidants were significantly decreased when exposure was given at 23 and 3 h GMT. The authors characterized their findings as indicating there may be adverse effects, stopping short of a definitive conclusion.
Exposure Details
- SAR
- 0.05653 W/kg
- Power Density
- 0.2017 mW/cm²
- Source/Device
- 1.8 GHz
- Exposure Duration
- 3, 7, 11, 15, 19 and 23 h GMT, respectively, for 2 h/day for 32 consecutive days
Exposure Context
This study used 0.2017 mW/cm² for radio frequency:
- 20.2Mx above the Building Biology guideline of 0.1 μW/m²
- 336.2Kx above the BioInitiative Report recommendation of 0.0006 μW/cm²
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To determine whether circadian rhythms of the plasma antioxidants (Mel, GSH-Px and SOD) are affected by RF, we performed a study on male Sprague Dawley rats exposed to the 1.8 GHz RF
All animals were divided into seven groups. The animals in six groups were exposed to 1.8 GHz RF (20...
Circadian rhythms in the synthesis of Mel and antioxidant enzymes, GSH-Px and SOD, were shifted in R...
The overall results indicate that there may be adverse effects of RF exposure on antioxidant function, in terms of both the daily antioxidative levels, as well as the circadian rhythmicity
Show BibTeX
@article{h_2015_circadian_rhythmicity_of_antioxidant_516,
author = {Cao H and Qin F and Liu X and Wang J and Cao Y and Tong J and Zhao H},
title = {Circadian Rhythmicity of Antioxidant Markers in Rats Exposed to 1.8 GHz Radiofrequency Fields},
year = {2015},
url = {https://www.mdpi.com/1660-4601/12/2/2071},
}