6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Oxidative Stress

Formation of Reactive Oxygen Species in L929 Cells after Exposure to 900 MHz RF Radiation with and without Co-exposure to 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

Bioeffects Seen

Zeni, O., Di Pietro, R., d'Ambrosio, G., Massa, R., Capri, M., Naarala, J., Juutilainen, J. and Scarfi, M. R. · 2007

View Original Abstract
Share:

Exposure to 900 MHz RF radiation, alone or combined with a chemical carcinogen, showed no indication of inducing reactive oxygen species in L929 cells.

Plain English Summary

Summary written for general audiences

Researchers investigated whether 900 MHz RF radiation could induce reactive oxygen species in murine L929 fibrosarcoma cells, with or without co-exposure to MX, a potent environmental carcinogen produced during chlorination of drinking water. Both continuous-wave and GSM mobile phone signals were applied for 10 or 30 min at specific absorption rates of 0.3 and 1 W/kg. The study found no indication that RF-field exposure, alone or combined with MX, induced reactive oxygen species formation, while MX alone caused a statistically significant increase in reactive oxygen species for all the treatment durations investigated.

Why This Matters

Both continuous-wave and GSM mobile phone signals were tested at specific absorption rates of 0.3 and 1 W/kg, applied for 10 or 30 minutes. MX was applied at a subtoxic level of 500 microM, and RF-field exposure was carried out during the first 10 or 30 min of the chemical treatment. Reactive oxygen species formation was measured soon after exposure and at different harvesting times until 1 hour after RF-field treatment. Simultaneous sham exposures were performed for each exposure condition. MX exposure resulted in a statistically significant increase in reactive oxygen species formation, confirming that MX is an inductor of oxidative stress in L929 cells.

Exposure Details

SAR
0.3, 1 W/kg
Source/Device
900 MHz
Exposure Duration
10 or 30 min

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.3, 1 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 5 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to investigate the induction of reactive oxygen species in murine L929 fibrosarcoma cells exposed to radiofrequency (RF) radiation at 900 MHz, with or without co-exposure to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent environmental carcinogen produced during chlorination of drinking water.

Both continuous-wave and GSM mobile phone signals were applied for 10 or 30 min at specific absorpti...

The studied provided no indication that 900 MHz RF-field exposure, either alone or in combination wi...

In contrast, exposure to MX resulted in a statistically significant increase in the formation of reactive oxygen species for all the treatment durations investigated, confirming that MX is an inductor of oxidative stress in L929 cells.

Cite This Study
Zeni, O., Di Pietro, R., d'Ambrosio, G., Massa, R., Capri, M., Naarala, J., Juutilainen, J. and Scarfi, M. R. (2007). Formation of Reactive Oxygen Species in L929 Cells after Exposure to 900 MHz RF Radiation with and without Co-exposure to 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. Radiat. Res. 167, 306-311, 2007.
Show BibTeX
@article{zeni_2007_formation_of_reactive_oxygen_583,
  author = {Zeni and O. and Di Pietro and R. and d'Ambrosio and G. and Massa and R. and Capri and M. and Naarala and J. and Juutilainen and J. and Scarfi and M. R.},
  title = {Formation of Reactive Oxygen Species in L929 Cells after Exposure to 900 MHz RF Radiation with and without Co-exposure to 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.},
  year = {2007},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/17316071/},
}
PubMed: 17316071

Cited By (50 papers)

Quick Questions About This Study

The study provided no indication that 900 MHz RF-field exposure induced formation of reactive oxygen species under any of the experimental conditions investigated.
Both continuous-wave and GSM mobile phone signals were applied for 10 or 30 min at specific absorption rates of 0.3 and 1 W/kg.
Exposure to MX resulted in a statistically significant increase in the formation of reactive oxygen species for all the treatment durations investigated.
Formation of reactive oxygen species was followed soon after the exposure and at different harvesting times until 1 hour after RF-field treatment.