RKIP-Mediated NF-κB Signaling is involved in ELF-MF-mediated improvement in AD rat.
Zuo H, Liu X, Wang D, Li Y, Xu X, Peng R, Song T. · 2018
View Original AbstractExposure to 50 Hz, 400 µT ELF-MF partially improved cognitive disorder in an Alzheimer's disease rat model and affected key proteins in the RKIP-mediated NF-κB signaling pathway.
Plain English Summary
Researchers created an Alzheimer's disease rat model using D-galactose and Aβ25-35 injections, then exposed the animals to 50 Hz and 400 µT ELF-MF for 60 continuous days. ELF-MF exposure partially improved the cognitive disorder and upregulated the levels of RKIP, TAK1, and the RKIP/TAK1 interaction, but downregulated p-IKK levels in AD rats. The researchers suggested that ELF-MF exposure might have a potential therapeutic value for AD.
Why This Matters
Spatial memory was tested using the Morris water maze after the 60-day exposure period. Protein expression and interactions were detected using western blotting and co-immunoprecipitation to examine RKIP-mediated NF-κB pathway factors. The results indicated that RKIP-mediated NF-κB pathway signaling plays an important role in the ELF-MF exposure-mediated improvements in the AD rat. The authors noted that further in-depth studies are required in the future.
Exposure Details
- Magnetic Field
- 0.4 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 60 continuous days
Exposure Context
This study used 0.4 mT for magnetic fields:
- 20Kx above the Building Biology guideline of 0.2 mG
- 4Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In this study, D-galactose intraperitoneal (50 mg/kg/d for 42 d) and Aβ25-35 hippocampal (5 μL/unilateral, bilateral, single-dose) injection were implemented to establish an AD rat model
Animals were exposed to 50 Hz and 400 µT ELF-MF for 60 continuous days. The spatial memory ability o...
Protein expression and interaction were detected by western blotting and co-immunoprecipitation for ...
Our study suggested that ELF-MF exposure might have a potential therapeutic value for AD. Further in depth studies are required in the future.
Show BibTeX
@article{h_2018_rkipmediated_nfb_signaling_is_740,
author = {Zuo H and Liu X and Wang D and Li Y and Xu X and Peng R and Song T.},
title = {RKIP-Mediated NF-κB Signaling is involved in ELF-MF-mediated improvement in AD rat.},
year = {2018},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299414/},
}