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Cellular Effects

Multinucleated giant cell appearance after whole body microwave irradiation of rats.

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Trosic I · 2001

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Multinucleated cells significantly increased (p<0.01) in rats after microwave irradiation, with the increase being time- and dose-dependent.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to 2450 MHz microwaves at power densities of 5 to 15 mW/cm², in sessions of two hours each, with groups receiving 2, 8, 13, or 22 treatments. Multinucleated cells significantly increased (p<0.01) in treated animals, with the elevation being time- and dose-dependent. Cell viability did not significantly change in the irradiated animal group compared with the control group.

Why This Matters

Free lung cell population was obtained by bronchoalveolar lavage and examined quantitatively, qualitatively, and morphologically. Macrophages with two nucleoli were more common in animals treated twice or eight times. Three or more nucleoli in a single cell were frequently observed after 13 or 22 treatments. Binucleation and multinucleation of alveolar macrophages were described as sensitive time- and dose-dependent morphological indicators of pulmonary stress. Total cell number retrieved by lavage slightly decreased in treated animals, also showing time- and dose-dependence.

Exposure Details

Power Density
5 – 15 mW/cm²
Source/Device
2450 MHz
Exposure Duration
2 h per day, 5 days per week for 30 days

Exposure Context

This study used 5 – 15 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 5 – 15 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)This level is 5 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

This study investigated the influence of 2450 MHz microwave irradiation on alveolar macrophage kinetics and formation of multinucleated giant cells after whole body irradiation of rats.

The range of electromagnetic radiation was selected as 2450 MHz microwaves at a power density of 5 –...

Total cell number retrieved by lavage slightly decreased in treated animals showing time- and dose-d...

Cite This Study
Trosic I (2001). Multinucleated giant cell appearance after whole body microwave irradiation of rats. Int J Hyg Environ Health. 204(2-3):133-138, 2001.
Show BibTeX
@article{i_2001_multinucleated_giant_cell_appearance_46,
  author = {Trosic I},
  title = {Multinucleated giant cell appearance after whole body microwave irradiation of rats.},
  year = {2001},
  
  url = {http://www.sciencedirect.com/science/article/pii/S1438463904700851},
}

Quick Questions About This Study

The exposure was set at 2450 MHz at a power density of 5 to 15 mW/cm².
Cell viability did not significantly change in the irradiated animal group compared with the control group.
Multinucleated cells significantly increased (p<0.01) in treated animals, with the elevation being time- and dose-dependent.
Two-nucleoli macrophages were more common after two or eight treatments, while polynucleation with three or more nucleoli was frequently observed after 13 or 22 treatments.
Binucleation and multinucleation of alveolar macrophages were described as sensitive time- and dose-dependent morphological indicators of pulmonary stress.