Exposure to ELF magnetic fields modulate redox related protein expression in mouse macrophages.
Frahm J, Mattsson MO, Simkó M. · 2010
View Original AbstractExposure of mouse macrophages to 50 Hz, 1.0 mT magnetic fields increased reactive oxygen species production and altered the expression of several redox-related proteins.
Plain English Summary
Researchers exposed mouse macrophages to a 50 Hz, 1.0 mT magnetic field and measured changes in reactive oxygen species production and protein expression. Short-term exposures of two hours or less caused slight and transient decreases in several proteins, including clathrin, adaptin, PI3-kinase, protein kinase B, and PP2A, while longer exposures had no effect on these proteins. The stress proteins Hsp70 and Hsp110 showed increased levels at certain time points but not generally.
Why This Matters
The researchers suggested that ELF magnetic fields interact with other cellular constituents than these chemicals, although the induced pathways at least partially converge. The NAD(P)H oxidase subunit gp91phox oscillated between increased and normal levels compared to controls over the course of exposure.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50 Hz
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
we present evidence that exposure of mouse macrophages to 50 Hz, 1.0 mT MF lead to immune cell activation seen as increased production of reactive oxygen species (ROS), and also to modulation on the expression level of important proteins acting in redox regulatory processes and thus explaining the noted changes in ROS levels seen after exposure.
The MF exposure caused slight and transient decreases after short term exposures (2 h or less) of cl...
Show BibTeX
@article{j_2010_exposure_to_elf_magnetic_368,
author = {Frahm J and Mattsson MO and Simkó M.},
title = {Exposure to ELF magnetic fields modulate redox related protein expression in mouse macrophages.},
year = {2010},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0378427409015197},
}