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Cellular Effects

Subchronic exposure of hsp70.1-deficient mice to radiofrequency radiation.

No Effects Found

Lee JS, Huang TQ, Lee JJ, Pack JK, Jang JJ, Seo JS. · 2005

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Even genetically vulnerable mice showed no cellular stress response to cell phone-level RF radiation at 0.4 W/kg over 10 weeks.

Plain English Summary

Summary written for general audiences

Researchers exposed genetically modified mice (lacking a key protective protein called HSP70) to cell phone radiation at 849 MHz and 1763 MHz frequencies for 10 weeks to see if repeated exposure would trigger cellular stress responses. Even though these mice were more vulnerable to stress than normal mice, the radiofrequency radiation at 0.4 W/kg caused no detectable changes in cell death, cell growth, or stress protein production. This suggests that moderate levels of RF radiation may not activate cellular stress pathways even in compromised organisms.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 849 MHz - 1.76 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 849 MHz - 1.76 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 849 MHz and 1763 MHz Duration: 45 min, with a 15 min interval, 5 days a week for 10 weeks

Study Details

We carried out a study to determine whether sub-chronic RF exposure can cause constitutive induction of a stress response at a cellular and/or molecular level in hsp70.1-deficient mice due to repeated stimulation.

Eight-week-old hsp70.1-deficient mice were exposed twice daily for 45 min, with a 15 min interval, 5...

No difference was observed in the histopathological analysis between sham- and RF-exposed mice. Ther...

The hsp70.1-deficient mice did not show any significant changes in terms of cell proliferation, apoptosis, or stress response due to exposure of 849 or 1,763 MHz RF fields.

Cite This Study
Lee JS, Huang TQ, Lee JJ, Pack JK, Jang JJ, Seo JS. (2005). Subchronic exposure of hsp70.1-deficient mice to radiofrequency radiation. Int J Radiat Biol. 81(10):781-792, 2005.
Show BibTeX
@article{js_2005_subchronic_exposure_of_hsp701deficient_3188,
  author = {Lee JS and Huang TQ and Lee JJ and Pack JK and Jang JJ and Seo JS.},
  title = {Subchronic exposure of hsp70.1-deficient mice to radiofrequency radiation.},
  year = {2005},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/16449085/},
}
PubMed: 16449085

Cited By (20 papers)

Quick Questions About This Study

A 2005 study found that cell phone radiation at 849 MHz and 1763 MHz frequencies caused no cellular stress in genetically vulnerable mice over 10 weeks. Even mice lacking protective HSP70 proteins showed no changes in cell death, growth, or stress responses.
Research using mice exposed to cell phone frequencies for 10 weeks found no increase in cell death (apoptosis) rates. The study specifically examined vulnerable mice lacking protective proteins, yet radiofrequency exposure at 0.4 W/kg produced no detectable cellular damage.
A controlled study exposing genetically modified mice to 849 MHz radiation for 10 weeks found no harmful effects on cellular health. Researchers detected no changes in cell proliferation, cell death, or protective protein levels compared to unexposed mice.
Ten weeks of radiofrequency exposure at cell phone frequencies did not affect stress protein levels in mice. The study measured HSP90, HSP70, and HSP25 proteins along with stress-activated enzymes, finding no significant changes from RF radiation exposure.
Research found no cellular risks from 1763 MHz radiation exposure in a 10-week mouse study. Even genetically vulnerable mice showed no changes in cell growth, death rates, or stress responses when exposed to this cell phone frequency.