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Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells.

Bioeffects Seen

Lupke M, Rollwitz J, Simkó M. · 2004

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Magnetic fields from power lines can increase harmful reactive oxygen species in immune cells by up to 50%.

Plain English Summary

Summary written for general audiences

German researchers exposed human immune cells (monocytes) to 50 Hz magnetic fields for 45 minutes and measured their production of reactive oxygen species (ROS), which are damaging molecules that contribute to cellular stress and disease. They found that magnetic field exposure increased ROS production by 20-50% in these immune cells. This matters because elevated ROS levels are linked to inflammation, aging, and various health problems.

Why This Matters

This study provides direct evidence that power frequency magnetic fields can trigger oxidative stress in human immune cells at levels well within everyday exposure ranges. The 1 mT (milliTesla) exposure used here is roughly equivalent to what you'd encounter standing directly under high-voltage power lines, but it's orders of magnitude higher than typical household exposures from appliances and wiring. What makes this research particularly significant is that it identifies a specific biological mechanism through which EMF exposure could contribute to health effects. The researchers found that magnetic fields activate cellular enzymes that produce reactive oxygen species, essentially putting immune cells into a state of oxidative stress. This finding fits into a broader pattern of research showing that EMF exposure can disrupt normal cellular processes, even when the energy levels are too low to cause heating. While this was a laboratory study using isolated cells rather than whole organisms, it demonstrates that magnetic fields can have measurable biological effects through well-understood biochemical pathways.

Exposure Details

Magnetic Field
1 mG
Source/Device
50 Hz
Exposure Duration
45 min

Exposure Context

This study used 1 mG for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 1 mGExtreme Concern5 mGFCC Limit2,000 mGEffects observed in the Severe Concern range (Building Biology)FCC limit is 2,000x higher than this exposure level

Study Details

The aim of this study was to investigate the mechanism of cell activation induced by extremely low frequency magnetic fields (ELF-MF) (50 Hz) in human cells.

We examined the production of free radicals in human umbilical cord blood-derived monocytes and in h...

Our results show a significant increase of superoxide radical anion production up-to 1.4 fold as wel...

Therefore, we suggest that ELF-MF exposure induces the activation of NADH oxidase in these cells. However, the MF-effect was inhibited by DPI in monocytes, indicating the activation of the NADPH oxidase after exposure to ELF-MF.

Cite This Study
Lupke M, Rollwitz J, Simkó M. (2004). Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells. Free Radic Res. 38(9):985-993, 2004.
Show BibTeX
@article{m_2004_cell_activating_capacity_of_412,
  author = {Lupke M and Rollwitz J and Simkó M.},
  title = {Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells.},
  year = {2004},
  doi = {10.1080/10715760400000968},
  url = {https://www.tandfonline.com/doi/abs/10.1080/10715760400000968},
}

Quick Questions About This Study

German researchers exposed human immune cells (monocytes) to 50 Hz magnetic fields for 45 minutes and measured their production of reactive oxygen species (ROS), which are damaging molecules that contribute to cellular stress and disease. They found that magnetic field exposure increased ROS production by 20-50% in these immune cells. This matters because elevated ROS levels are linked to inflammation, aging, and various health problems.