A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains
Carballo-Quintás M, Martínez-Silva I, Cadarso-Suárez C, Alvarez-Figueiras M, Ares-Pena FJ, López-Martín E · 2011
View Original AbstractIn rats exposed to 900 MHz GSM radiation combined with picrotoxin, both the neuronal marker c-fos and glial marker GFAP were triggered by the combined stress.
Plain English Summary
Researchers studied the effects of acute 900 MHz GSM radiation exposure on neurotoxic biomarkers c-fos and GFAP in rats also treated with picrotoxin, a seizure-promoting agent. Seventy-two adult male Sprague-Dawley rats underwent immunochemical testing to measure c-fos induction after 90 minutes and 24 hours, and GFAP 72 hours after acute exposure to a 900 MHz electromagnetic field. The results indicated that c-fos and glial markers were triggered by the combined stress of non-thermal irradiation and the toxic effect of picrotoxin on brain tissue.
Why This Matters
The average specific absorption rate was 1.45 W/kg in picrotoxin-treated rats and 1.38 W/kg in untreated rats. Ninety minutes after radiation, high levels of c-fos expression were recorded in the neocortex and paleocortex, along with low hippocampus activation in picrotoxin-treated animals. Most brain areas, except the limbic cortical region, showed important increases in neuronal activation 24 hours after picrotoxin and radiation. Three days after picrotoxin treatment, radiation effects were still apparent in the neocortex, dentate gyrus, and CA3, but a significant decrease in activity was noted in the piriform and entorhinal cortex. Glial reactivity increased with every seizure in irradiated, picrotoxin-treated brain regions.
Exposure Details
- SAR
- 1.45 and 1.38 W/kg
- Source/Device
- 900 MHz microwaves
- Exposure Duration
- continuous for 2 h
Exposure Context
This study used 1.45 and 1.38 W/kg for SAR (device absorption):
- 3.4x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The objective of the study was to investigate effects of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains
The acute effects of microwave exposure from the Global System for Mobile Communication (GSM) were s...
Ninety minutes after radiation high levels of c-fos expression were recorded in the neocortex and pa...
Our results reveal that c-fos and glial markers were triggered by the combined stress of non-thermal irradiation and the toxic effect of picrotoxin on cerebral tissues.
Show BibTeX
@article{m_2011_a_study_of_neurotoxic_78,
author = {Carballo-Quintás M and Martínez-Silva I and Cadarso-Suárez C and Alvarez-Figueiras M and Ares-Pena FJ and López-Martín E},
title = {A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains},
year = {2011},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0161813X11000751},
}