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Oxidative Stress

Oxidative stress and apoptosis in relation to exposure to magnetic field

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Emre M, Cetiner S, Zencir S, Unlukurt I, Kahraman I, Topcu Z · 2011

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Exposure to extremely low-frequency electromagnetic fields was associated with increased oxidative stress indicators in rat liver tissue, though DNA analyses did not differentiate between exposed and control groups.

Plain English Summary

Summary written for general audiences

Researchers investigated the effect of extremely low-frequency electromagnetic field exposure with pulse trains on lipid peroxidation and oxidative stress in rat liver tissue. The study used 30 adult male Wistar rats and measured plasma enzyme and protein levels, as well as apoptotic and necrotic cell percentages in kidney extracts. Oxidative stress indicators increased, and necrotic cell percentages were significantly lower in exposed animals compared to unexposed or sham control groups, though DNA ladder analyses did not differentiate between the groups.

Why This Matters

Flow cytometric data suggested a possible relationship between exposure to magnetic field and cell death. Apoptotic cell death was further characterized by monitoring DNA degradation using gel electrophoresis. Despite the flow cytometry findings, DNA ladder analyses did not differentiate between the exposed and control groups.

Exposure Details

Magnetic Field
1.5 mT
Electric Field
0.6 V/m
Source/Device
1–40 Hz
Exposure Duration
1 h/day for 30 days

Exposure Context

This study used 1.5 mT for magnetic fields:

This study used 0.6 V/m for electric fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 8 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 40 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 40 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

We investigated the effect of extremely low-frequency electromagnetic field (ELF-EMF) with pulse trains exposure on lipid peroxidation, and, hence, oxidative stress in the rat liver tissue.

The parameters that we measured were the levels of plasma alanine aminotransferase, aspartate aminot...

The results showed an increase in the levels of oxidative stress indicators, and the flow cytometric...

Cite This Study
Emre M, Cetiner S, Zencir S, Unlukurt I, Kahraman I, Topcu Z (2011). Oxidative stress and apoptosis in relation to exposure to magnetic field Cell Biochem Biophys. 59(2):71-77, 2011.
Show BibTeX
@article{m_2011_oxidative_stress_and_apoptosis_353,
  author = {Emre M and Cetiner S and Zencir S and Unlukurt I and Kahraman I and Topcu Z},
  title = {Oxidative stress and apoptosis in relation to exposure to magnetic field},
  year = {2011},
  doi = {10.1007/s12013-010-9113-0},
  url = {https://link.springer.com/article/10.1007/s12013-010-9113-0},
}
DOI: 10.1007/s12013-010-9113-0

Cited By (58 papers)

View all 58 citing papers on Semantic Scholar

Quick Questions About This Study

The study examined extremely low-frequency electromagnetic field exposure delivered with pulse trains.
The study used 30 adult male Wistar rats.
Exposed animals showed significantly lower necrotic cell percentages compared to either unexposed or sham control groups.
DNA ladder analyses did not differentiate between the exposed and control groups.
Researchers measured plasma alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, bilirubin, and total protein levels.