Effects of long-term exposure of extremely low frequency magnetic field on oxidative/nitrosative stress in rat liver.
Erdal N, Gürgül S, Tamer L, Ayaz L · 2008
View Original AbstractIn exposed female rats, 3-NT levels were significantly increased compared to female controls, while no significant differences were found in male rats or in MDA levels in either sex.
Plain English Summary
Researchers exposed adult Wistar-Albino rats to an extremely low frequency magnetic field (50 Hz, 1 mT, 4 hours per day) to study oxidative and nitrosative stress in liver tissue. 3-nitrotyrosine (3-NT) levels were significantly increased in exposed female rats compared to female controls, but no significant difference was found between exposed and control male rats. Malondialdehyde (MDA) levels showed no significant differences between control and exposed rats in either sex.
Why This Matters
The rats were divided into four groups of eight: female controls, MF-exposed females, male controls, and MF-exposed males. Liver tissue from each animal was harvested and used to measure MDA and 3-nitrotyrosine (3-NT). MDA was measured by the MDA-TBA method, while 3-NT levels were determined by the HPLC-UV system. The researchers suggest that long-term ELF-MF exposure may enhance oxidative/nitrosative stress in liver tissue of female rats and could have a deteriorative effect on cellular proteins by enhancing 3-NT formation.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50Hz
- Exposure Duration
- 4h/day for 45 days
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
Thirty-two adult Wistar-Albino female and male rats were used to investigate the long-term (45 days) effects of extremely low frequency magnetic field (ELF-MF; 50Hz, 1mT, 4h/day) exposure on oxidative/nitrosative stress in liver tissues of rats.
The rats were divided randomly into four groups: female control (FC; n = 8) and MF-exposed female ra...
There were no significant differences between the MDA levels of the control (FC; MC) and MF-exposed ...
In conclusion, our study suggests that the long-term ELF-MF exposure may enhance the oxidative/nitrosative stress in liver tissue of the female rats and could have a deteriorative effect on cellular proteins rather than lipids by enhancing 3-NT formation.
Show BibTeX
@article{n_2008_effects_of_longterm_exposure_354,
author = {Erdal N and Gürgül S and Tamer L and Ayaz L},
title = {Effects of long-term exposure of extremely low frequency magnetic field on oxidative/nitrosative stress in rat liver.},
year = {2008},
url = {https://academic.oup.com/jrr/article/49/2/181/935400?login=true},
}