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Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells.

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Eghlidospour M, Ghanbari A, Mortazavi SMJ, Azari H. · 2017

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Exposure to GSM 900-MHz RF-EMF reduced neurosphere number and size and neuronal differentiation but did not affect cell viability, apoptosis, or astrocytic differentiation.

Plain English Summary

Summary written for general audiences

Researchers exposed adult murine neural stem cells to GSM 900-MHz radiofrequency radiation from a mobile phone for varying durations. They used neurosphere assays to evaluate proliferation, immunofluorescence to examine differentiation, and alamarBlue and caspase 3 apoptosis assays to assess harmful effects. Neurosphere number and size and the proportion of cells becoming neurons decreased significantly with longer exposure. Cell viability, apoptosis, and astrocytic differentiation were unchanged.

Why This Matters

The authors concluded that accumulating dose of GSM 900-MHz RF-EMF might have devastating effects on neural stem cell proliferation and neurogenesis. They suggested this requires more causations in terms of using mobile devices.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: GSM 900-MHz

Study Details

The main goal of this study was to evaluate the effects of radiofrequency radiation emitted from a GSM 900-MHz mobile phone with different exposure duration on proliferation, differentiation and apoptosis of adult murine NSCs in vitro

We used neurosphere assay to evaluate NSCs proliferation, and immunofluorescence assay of neural cel...

Our results showed that the number and size of resulting neurospheres and also the percentage of cel...

. It is concluded that accumulating dose of GSM 900-MHz RF-EMF might have devastating effects on NSCs proliferation and neurogenesis requiring more causations in terms of using mobile devices.

Cite This Study
Eghlidospour M, Ghanbari A, Mortazavi SMJ, Azari H. (2017). Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells. Anat Cell Biol. 50(2):115-123, 2017.
Show BibTeX
@article{m_2017_effects_of_radiofrequency_exposure_2049,
  author = {Eghlidospour M and Ghanbari A and Mortazavi SMJ and Azari H.},
  title = {Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/28713615/},
}
PubMed: 28713615

Cited By (51 papers)

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Quick Questions About This Study

The study used GSM 900-MHz radiofrequency radiation emitted from a mobile phone with different exposure durations.
Neurosphere number and size decreased significantly with increasing exposure duration.
The percentage of cells differentiated into neurons decreased significantly, while astrocytic differentiation was not influenced.
Cell viability and apoptosis were not influenced by exposure at different durations.
They concluded that accumulating dose of GSM 900-MHz RF-EMF might have devastating effects on neural stem cell proliferation and neurogenesis, requiring more causations in terms of using mobile devices.