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Selenium Reduces Mobile Phone (900 MHz)-Induced Oxidative Stress, Mitochondrial Function, and Apoptosis in Breast Cancer Cells.

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Kahya MC, Nazıroğlu M, Ciğ B. · 2014

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In breast cancer cells, 900 MHz radiation appeared to induce oxidative stress and apoptosis, and selenium seemed to counteract these effects.

Plain English Summary

Summary written for general audiences

Researchers studied the effects of 900 MHz radiation on oxidative stress, apoptosis, and mitochondrial depolarization in a breast cancer cell line. Cells were exposed to 900 MHz radiation for 1 hour at a SAR value of 0.36 ± 0.02 W/kg, and some groups were also incubated with sodium selenite before exposure.

Why This Matters

The experiment divided cancer cell cultures into four groups: controls, selenium only, radiation only, and radiation plus selenium. Researchers measured cell viability, intracellular ROS production, mitochondrial membrane depolarization, cell apoptosis, and caspase-3 and caspase-9 values. The study suggested that exposure to electromagnetic radiation may affect biological systems by increasing free oxygen radicals, apoptosis, and mitochondrial depolarization, and that selenium may modulate these values in cancer.

Exposure Details

SAR
0.36 ± 0.02 W/kg
Source/Device
900 MHz
Exposure Duration
1 hour

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.36 ± 0.02 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Severe Concern range (Building Biology)FCC limit is 80 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The present study was designed to investigate the effects of 900 MHz radiation on the antioxidant redox system, apoptosis, and mitochondrial depolarization levels in MDA-MB-231 breast cancer cell line.

Cultures of the cancer cells were divided into four main groups as controls, selenium, EMR, and EMR ...

Selenium suppressed EMR-induced oxidative cell damage and cell viability (MTT) through a reduction o...

In conclusion, 900 MHz EMR appears to induce apoptosis effects through oxidative stress and mitochondrial depolarization although incubation of selenium seems to counteract the effects on apoptosis and oxidative stress.

Cite This Study
Kahya MC, Nazıroğlu M, Ciğ B. (2014). Selenium Reduces Mobile Phone (900 MHz)-Induced Oxidative Stress, Mitochondrial Function, and Apoptosis in Breast Cancer Cells. Biol Trace Elem Res. 2014 Jun 27.
Show BibTeX
@article{mc_2014_selenium_reduces_mobile_phone_1086,
  author = {Kahya MC and Nazıroğlu M and Ciğ B.},
  title = {Selenium Reduces Mobile Phone (900 MHz)-Induced Oxidative Stress, Mitochondrial Function, and Apoptosis in Breast Cancer Cells.},
  year = {2014},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/24965080/},
}
PubMed: 24965080

Cited By (53 papers)

View all 53 citing papers on Semantic Scholar

Quick Questions About This Study

The study used the MDA-MB-231 breast cancer cell line.
Cells were exposed to 900 MHz radiation for 1 hour at a SAR value of 0.36 ± 0.02 W/kg.
Selenium suppressed radiation-induced oxidative cell damage through a reduction of oxidative stress and by restoring mitochondrial membrane potential.
The study found that 900 MHz radiation appears to induce apoptosis effects through oxidative stress and mitochondrial depolarization.
Apoptosis was assessed by plate reader analyses of apoptosis levels and caspase-3 and caspase-9 values.