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Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields.

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Repacholi, MH, Basten, A, Gebski, V, Noonan, D, Finnie, J, Harris, AW · 1997

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Exposed mice had a significantly higher lymphoma risk than controls (OR = 2.4, P = 0.006).

Plain English Summary

Summary written for general audiences

Researchers exposed female E mu-Pim1 transgenic mice to pulsed 900 MHz fields for two 30-minute periods per day for up to 18 months. Lymphoma risk was significantly higher in exposed mice than in controls (OR = 2.4, P = 0.006). Follicular lymphomas were the major contributor to the increased tumor incidence.

Why This Matters

The study aimed to determine whether long-term exposure to pulse-modulated RF fields similar to those used in digital mobile telecommunications would increase lymphoma incidence in E mu-Pim1 transgenic mice that are moderately predisposed to develop lymphoma spontaneously. The researchers suggested that genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for cancer risk after RF-field exposure. Exposure parameters included incident power densities of 2.6-13 W/m2 and specific absorption rates of 0.008-4.2 W/kg, averaging 0.13-1.4 W/kg.

Exposure Details

SAR
0.008-4.2 , 0.13-1.4 W/kg
Power Density
0.26, 1.3 mW/cm²
Source/Device
900 MHZ
Exposure Duration
30 min up to 18 months

Exposure Context

This study used 0.26, 1.3 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.26, 1.3 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)FCC limit is 4 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of the present study was to determine whether long-term exposure to pulse-modulated RF fields similar to those used in digital mobile telecommunications would increase the incidence of lymphoma in E mu-Pim1 transgenic mice, which are moderately predisposed to develop lymphoma spontaneously.

One hundred female E mu-Pim1 mice were sham-exposed and 101 were exposed for two 30-min periods per...

Lymphoma risk was found to be significantly higher in the exposed mice than in the controls (OR = 2....

We suggest that such genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for risk of cancer after RF-field exposure.

Cite This Study
Repacholi, MH, Basten, A, Gebski, V, Noonan, D, Finnie, J, Harris, AW (1997). Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. Radiat Res 147(5):631-640, 1997.
Show BibTeX
@article{repacholi_1997_lymphomas_in_e_mupim1_1292,
  author = {Repacholi and MH and Basten and A and Gebski and V and Noonan and D and Finnie and J and Harris and AW},
  title = {Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields.},
  year = {1997},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/9146709/},
}
PubMed: 9146709

Cited By (449 papers)

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Quick Questions About This Study

Mice were exposed for two 30-minute periods per day for up to 18 months to 900 MHz fields with a pulse repetition frequency of 217 Hz and pulse width of 0.6 ms.
Lymphoma risk was significantly higher in exposed mice than in controls with an odds ratio of 2.4 (P = 0.006).
Follicular lymphomas were the major contributor to the increased tumor incidence.
The researchers suggested that genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for cancer risk after RF-field exposure.