Assessment of genotoxic and cytotoxic hazards in brain and bone marrow cells of newborn rats exposed to extremely low-frequency magnetic field.
Rageh MM, El-Gebaly RH, El-Bialy NS. · 2012
View Original AbstractThis study suggests an association between ELF-MF exposure and DNA damage in newborn rats.
Plain English Summary
Researchers exposed newborn rats continuously to a 50 Hz, 0.5 mT extremely low-frequency magnetic field for 30 days, starting when the rats were 10 days old. DNA damage in brain cells, measured by comet assay, was significantly higher in the exposed group. Exposure was associated with a significant four-fold increase in micronucleus induction and about a three-fold increase in mitotic index in bone marrow cells. Exposed rats also showed significantly higher levels of MDA and SOD, while ELF-MF failed to alter the activity of GSH.
Why This Matters
The study aimed to evaluate the association between whole-body exposure to extremely low-frequency magnetic field and genotoxic and cytotoxic hazards in brain and bone marrow cells of newborn rats. A control group was treated identically to the exposed group, with the only difference being that those rats were not exposed to the magnetic field. DNA damage in brain cells was assessed using the comet assay, which measured the mean tail moment as an indicator of damage. Bone marrow cells were examined for micronucleus induction and mitotic index, both of which increased significantly in exposed animals. The researchers framed their conclusion as a suggested association, not a proven causal relationship.
Exposure Details
- Magnetic Field
- 0.5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 30 days
Exposure Context
This study used 0.5 mT for magnetic fields:
- 25Kx above the Building Biology guideline of 0.2 mG
- 5Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The present study aimed to evaluate the association between whole body exposure to extremely low frequency magnetic field (ELF-MF) and genotoxic , cytotoxic hazards in brain and bone marrow cells of newborn rats.
Newborn rats (10 days after delivery) were exposed continuously to 50 Hz, 0.5 mT for 30 days. The co...
The results showed a significant increase in the mean tail moment indicating DNA damage in exposed g...
In conclusion, the present study suggests an association between DNA damage and ELF-MF exposure in newborn rats.
Show BibTeX
@article{mm_2012_assessment_of_genotoxic_and_288,
author = {Rageh MM and El-Gebaly RH and El-Bialy NS.},
title = {Assessment of genotoxic and cytotoxic hazards in brain and bone marrow cells of newborn rats exposed to extremely low-frequency magnetic field.},
year = {2012},
url = {https://www.hindawi.com/journals/bmri/2012/716023/},
}