Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study.
Lee BC, Johng HM, Lim JK, Jeong JH, Baik KY, Nam TJ, Lee JH, Kim J, Sohn UD, Yoon G, Shin S, Soh KS. · 2004
View Original AbstractExposure to a 60 Hz magnetic field for 3 hours significantly increased both a measure of oxidative stress and antioxidant enzyme activity in mouse brain.
Plain English Summary
Researchers investigated whether a 60 Hz magnetic field could affect the antioxidant defense system in mouse brain by measuring chemiluminescence and superoxide dismutase (SOD) activity in brain homogenates. A chemiluminescence measure linked to oxidative stress was significantly increased in mice exposed to 60 Hz, 12 G for 3 hours compared to the sham-exposed control group. Brain SOD activity was also significantly increased in the exposed group. The researchers suggest these results indicate the field could deteriorate the antioxidant defensive system through reactive oxygen species other than superoxide radicals.
Why This Matters
One measure, lucigenin-initiated chemiluminescence, was not significantly increased in exposed mice compared to controls. The other chemiluminescence measure, which used TBHP to amplify the signal, was significantly increased in the exposed group. SOD is described as playing a critical role in the antioxidant defensive system in the brain. The authors called for further studies to identify what kind of reactive oxygen species are generated by exposure to the 60 Hz field.
Exposure Details
- Magnetic Field
- 1.2 mT
- Source/Device
- 60 Hz
- Exposure Duration
- 3 h
Exposure Context
This study used 1.2 mT for magnetic fields:
- 60Kx above the Building Biology guideline of 0.2 mG
- 12Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We investigated whether ELF (60 Hz) MF can modulate antioxidant system in mouse brain by detecting chemiluminescence and measuring superoxide dismutase (SOD) activity in homogenates of the organ.
Compared to sham exposed control group, lucigenin-initiated chemiluminescence in exposed group was n...
These results suggest that 60 Hz, MF could deteriorate antioxidant defensive system by reactive oxygen species (ROS), other than superoxide radicals. Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress.
Show BibTeX
@article{bc_2004_effects_of_extremely_low_406,
author = {Lee BC and Johng HM and Lim JK and Jeong JH and Baik KY and Nam TJ and Lee JH and Kim J and Sohn UD and Yoon G and Shin S and Soh KS. },
title = {Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study.},
year = {2004},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1011134403001519},
}