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Brain & Nervous System

Evaluation of bax, bcl-2, p21 and p53 genes expression variations on cerebellum of BALB/c mice before and after birth under mobile phone radiation exposure.

No Effects Found

Ghatei N, Nabavi AS, Toosi MHB, Azimian H, Homayoun M, Targhi RG, Haghir H. · 2017

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Cell phone radiation altered brain gene expression in developing mice, showing biological effects even when cell death wasn't triggered.

Plain English Summary

Summary written for general audiences

Researchers exposed pregnant mice and their offspring to cell phone radiation at 900 and 1800 MHz frequencies, then examined how this affected genes related to cell death and DNA repair in the brain's cerebellum. They found that the radiation did not trigger cell death pathways but did alter expression of genes involved in DNA repair. The authors concluded that while cell phone radiation may cause some cellular changes, the brain appears capable of repairing any damage through normal cellular mechanisms.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 900 and 1800 MHz

Study Details

We examined the effect of mobile phones radiation on genes expression variation on cerebellum of BALB/c mice before and after of the birth.

In this study, a mobile phone jammer, which is an instrument to prevent receiving signals between ce...

The data showed that mobile phone radio waves were ineffective on the expression level of bcl-2 and ...

From the obtained data it could be concluded that the mobile phone radiations did not induce apoptosis in cells of the cerebellum and the injured cells can be repaired by cell cycle arrest.

Cite This Study
Ghatei N, Nabavi AS, Toosi MHB, Azimian H, Homayoun M, Targhi RG, Haghir H. (2017). Evaluation of bax, bcl-2, p21 and p53 genes expression variations on cerebellum of BALB/c mice before and after birth under mobile phone radiation exposure. Iran J Basic Med Sci. 20(9):1037-1043, 2017.
Show BibTeX
@article{n_2017_evaluation_of_bax_bcl2_3038,
  author = {Ghatei N and Nabavi AS and Toosi MHB and Azimian H and Homayoun M and Targhi RG and Haghir H.},
  title = {Evaluation of bax, bcl-2, p21 and p53 genes expression variations on cerebellum of BALB/c mice before and after birth under mobile phone radiation exposure.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/29085599/},
}
PubMed: 29085599

Cited By (26 papers)

Quick Questions About This Study

A 2017 study found that 900 and 1800 MHz cell phone radiation did not trigger cell death (apoptosis) in cerebellum tissue of exposed mice. The radiation failed to activate typical cell death pathways, suggesting the brain tissue remained viable despite exposure.
Research on pregnant mice exposed to cell phone radiation showed altered expression of DNA repair genes in offspring's cerebellum tissue. Specifically, p21 gene expression increased while bax decreased, indicating the brain activated repair mechanisms rather than cell death pathways.
A study testing both 900 MHz and 1800 MHz cell phone frequencies found similar effects on mouse cerebellum tissue. Neither frequency triggered significant cell death, and both appeared to activate cellular repair mechanisms through altered gene expression patterns.
Cell phone radiation at 900 and 1800 MHz frequencies did not significantly affect bcl-2 and p53 gene expression levels in mouse cerebellum tissue. These genes, which regulate cell survival and DNA repair, remained stable despite radiation exposure.
Research indicates brain cells can repair potential damage from mobile phone radiation through cell cycle arrest mechanisms. A 2017 study found that exposed cerebellum tissue activated repair pathways rather than cell death, suggesting effective cellular recovery processes.