The expression of pluripotency and neuronal differentiation markers under the influence of electromagnetic field and nitric oxide.
Haghighat N, Abdolmaleki P, Parnian J, Behmanesh M. · 2017
View Original AbstractPower line frequency EMF can force stem cells to differentiate prematurely, potentially compromising the body's natural repair mechanisms.
Plain English Summary
Researchers exposed stem cells from rat bone marrow to 50 Hz electromagnetic fields (the same frequency as power lines) combined with nitric oxide, a natural cellular messenger. They found that EMF exposure combined with high levels of nitric oxide forced stem cells to transform into nerve cells, while low nitric oxide levels helped protect the cells' original stem cell properties. This suggests that EMF exposure can influence how our cells develop and differentiate, potentially affecting tissue repair and regeneration.
Why This Matters
This study reveals a concerning mechanism by which power frequency EMF exposure can alter fundamental cellular processes. The researchers demonstrated that 50 Hz EMF - the same frequency emitted by electrical wiring, appliances, and power lines in our homes - can push stem cells toward premature differentiation when combined with cellular stress factors like nitric oxide. What makes this particularly significant is that stem cells are crucial for tissue repair and regeneration throughout our bodies. The science demonstrates that EMF exposure doesn't just affect cells in isolation, but can amplify the effects of other biological stressors in ways that could compromise our body's natural healing processes. While we're exposed to 50 Hz fields daily from our electrical infrastructure, this research suggests these exposures may be interfering with cellular repair mechanisms in ways we're only beginning to understand.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 50 Hz
Study Details
The aim of this study is to observe The expression of pluripotency and neuronal differentiation markers under the influence of electromagnetic field and nitric oxide
The cells were treated with low (50micromolar) and high (1mM) concentrations of Deta-NO as a NO dono...
The simultaneous treatment of EMF with NO (1mM) led to the down-regulation of stemness markers expre...
NO low concentration helped the cells protect the stemness state but NO high concentration plus EMF pushed cells into differentiation pathway.
Show BibTeX
@article{n_2017_the_expression_of_pluripotency_1746,
author = {Haghighat N and Abdolmaleki P and Parnian J and Behmanesh M.},
title = {The expression of pluripotency and neuronal differentiation markers under the influence of electromagnetic field and nitric oxide.},
year = {2017},
url = {https://pubmed.ncbi.nlm.nih.gov/28843440/},
}