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Effect of Exposure to 900 MHz GSM Mobile Phone Radiofrequency Radiation on Estrogen Receptor Methylation Status in Colon Cells of Male Sprague Dawley Rats.

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Mokarram P, Sheikhi M, Mortazavi SMJ, Saeb S4 Shokrpour N · 2017

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Exposure to GSM mobile phone RF radiation altered ERα gene methylation in rat colon cells, and no adaptive response was induced after a gamma-ray challenge dose.

Plain English Summary

Summary written for general audiences

Exposure to RF radiation altered the ERα gene methylation pattern compared to non-exposed controls. A subsequent gamma-ray challenge dose did not induce an adaptive response in ERα methylation. The study concluded that GSM mobile phone RF radiation can lead to epigenetic detrimental changes in ERα promoter methylation.

Why This Matters

The study aimed to test whether the epigenetic pattern of ERα is susceptible to RF radiation and whether RF radiation can induce a radioadaptive response after a gamma-ray challenge dose. Rats were divided into four groups: RF exposure only, RF exposure followed by gamma radiation, gamma radiation only, and a control group.

Study Details

This study aimed to investigate whether epigenetic pattern of ERα is susceptible to RF radiation and if RF radiation can induce radioadaptive response as epigenetic changes after receiving the challenge dose (γ-ray).

40 male Sprague-Dawley rats were divided into 4 equal groups (Group I: exposure to RF radiation of a...

Our finding showed that exposure to GSM cell phone RF radiation was capable of altering the pattern ...

It can be concluded that exposure to RF radiation emitted by GSM mobile phones can lead to epigenetic detrimental changes in ERα promoter methylation pattern.

Cite This Study
Mokarram P, Sheikhi M, Mortazavi SMJ, Saeb S4 Shokrpour N (2017). Effect of Exposure to 900 MHz GSM Mobile Phone Radiofrequency Radiation on Estrogen Receptor Methylation Status in Colon Cells of Male Sprague Dawley Rats. J Biomed Phys Eng. 7(1):79-86, 2017.
Show BibTeX
@article{p_2017_effect_of_exposure_to_2409,
  author = {Mokarram P and Sheikhi M and Mortazavi SMJ and Saeb S4 Shokrpour N},
  title = {Effect of Exposure to 900 MHz GSM Mobile Phone Radiofrequency Radiation on Estrogen Receptor Methylation Status in Colon Cells of Male Sprague Dawley Rats.},
  year = {2017},
  
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401136/},
}

Quick Questions About This Study

Rats were divided into four groups: one received GSM phone RF radiation for 4 hours, another received RF radiation followed by a 3 Gy gamma-ray dose, a third received only the gamma-ray dose, and a fourth served as controls.
Exposure to GSM mobile phone RF radiation altered the ERα gene methylation pattern compared to non-exposed controls.
No adaptive response phenomenon was induced in the ERα gene methylation pattern after exposure to the challenging dose of Co-60 gamma rays.
DNA from colon tissues was extracted to evaluate the methylation status by methylation-specific PCR.
The researchers concluded that exposure to RF radiation emitted by GSM mobile phones can lead to epigenetic detrimental changes in ERα promoter methylation pattern.