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The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states.

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Bodera P, Makarova K, Zawada K, Antkowiak B, Paluch M, Sobiczewska E, Sirav B, Siwicki AK, Stankiewicz W · 2017

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Cell phone radiation caused measurable oxidative stress in rat brains after just 75 minutes of total exposure.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to cell phone radiation (1800 MHz) to study brain effects. They found no changes in healthy rats, but radiation combined with existing inflammation affected brain receptors involved in learning and memory, suggesting inflamed brains may be more vulnerable.

Why This Matters

This study adds to the growing body of research suggesting that cell phone radiation can trigger oxidative stress in brain tissue, even at relatively short exposure durations. The 1800 MHz frequency used here is identical to GSM cell phone signals that millions of people are exposed to daily through their phones. What's particularly noteworthy is that the researchers found 'robust' oxidative stress effects using the ORAC test, which measures the brain's ability to neutralize harmful free radicals. The fact that effects were more pronounced in rats with pre-existing inflammation suggests that people with certain health conditions might be more vulnerable to EMF exposure. While the study's authors called their results 'equivocal,' the oxidative stress findings align with dozens of other studies showing that radiofrequency radiation can overwhelm cellular antioxidant defenses, potentially leading to long-term neurological effects.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 1800 MHz GSM Modulated Duration: 5 times for 15 min

Study Details

The aim of this study was to evaluate the effect of repeated exposure (5 times for 15 min) of 1800 MHz radio-frequency radiation (RFR) on N-methyl-d-aspartate receptor subunit NR1 (NMDA-NR1) expression in the brains of rats in a persistent inflammatory state. We also measured the effect of RFR combined with tramadol (TRAM) to determine the potential antioxidant capacity of this agent.

The effects of the Global System for Mobile Communication (GSM) modulated 1800 MHz RFR exposure on t...

No differences between the baseline group and the exposed group (RFR) were observed. NMDA-NR1 expres...

ORAC assessment revealed a robust effect of RFR, however the other experiments revealed equivocal effects. Further studies examining the combination of ORAC with NMDA are warranted to elucidate more clearly the effect of RFR on the brain.

Cite This Study
Bodera P, Makarova K, Zawada K, Antkowiak B, Paluch M, Sobiczewska E, Sirav B, Siwicki AK, Stankiewicz W (2017). The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states. Biomed Pharmacother. 92:802-809, 2017.
Show BibTeX
@article{p_2017_the_effect_of_1800_1576,
  author = {Bodera P and Makarova K and Zawada K and Antkowiak B and Paluch M and Sobiczewska E and Sirav B and Siwicki AK and Stankiewicz W},
  title = {The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states.},
  year = {2017},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S075333221731394X},
}

Quick Questions About This Study

A 2017 rat study found that 1800 MHz GSM radiation alone didn't affect NMDA receptors in healthy brains. However, when combined with existing inflammation, the radiation decreased NMDA-NR1 receptor expression, which plays a role in learning and memory functions.
Research suggests yes. A 2017 study found that while 1800 MHz radiation had no effect on healthy rat brains, it significantly impacted brain receptors when inflammation was already present, indicating inflamed brain tissue may be more susceptible to EMF effects.
A 2017 study found that 1800 MHz GSM radiation combined with brain inflammation decreased NMDA-NR1 receptor expression in rats. These receptors are crucial for learning and memory, suggesting potential cognitive impacts when inflammation is present in the brain.
ORAC (Oxygen Radical Absorbance Capacity) measures antioxidant activity in tissues. In a 2017 brain study, ORAC assessment revealed robust effects from 1800 MHz radiation exposure, indicating potential oxidative stress changes even when other brain markers showed mixed results.
According to 2017 research, healthy rat brains showed no changes when exposed to 1800 MHz GSM radiation. The study found that radiation effects only became apparent when brain inflammation was already present, suggesting healthy tissue has natural protective mechanisms.