The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states.
Bodera P, Makarova K, Zawada K, Antkowiak B, Paluch M, Sobiczewska E, Sirav B, Siwicki AK, Stankiewicz W · 2017
View Original AbstractRepeated 1800 MHz RFR exposure did not change NMDA-NR1 expression versus baseline, but decreased it in inflamed rats and increased it in healthy controls, while ORAC showed a robust RFR effect.
Plain English Summary
Researchers evaluated the effect of repeated 1800 MHz RFR exposure (5 times for 15 min) on NMDA-NR1 expression in rat brains in a persistent inflammatory state. They also measured the effect of RFR combined with tramadol to determine its potential antioxidant capacity. No differences in NMDA-NR1 expression were observed between baseline and RFR-exposed groups. NMDA-NR1 expression decreased after CFA injection combined with RFR exposure, while elevated expression was observed in healthy control rats exposed to RFR with or without tramadol. ORAC assessment revealed a robust effect of RFR, but other experiments showed equivocal effects.
Why This Matters
The study used GSM-modulated 1800 MHz RFR and measured effects using ORAC and ESR detection of hydroxyl radicals. NMDA-NR1 was measured in cerebral tissue of rats with inflammation induced by complete Freund's adjuvant and in rats injected with tramadol after RFR exposure, as well as non-exposed baseline and tramadol-only groups. The authors suggest further studies combining ORAC with NMDA to clarify RFR effects on the brain.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 1800 MHz GSM Modulated Duration: 5 times for 15 min
Study Details
The aim of this study was to evaluate the effect of repeated exposure (5 times for 15 min) of 1800 MHz radio-frequency radiation (RFR) on N-methyl-d-aspartate receptor subunit NR1 (NMDA-NR1) expression in the brains of rats in a persistent inflammatory state. We also measured the effect of RFR combined with tramadol (TRAM) to determine the potential antioxidant capacity of this agent.
The effects of the Global System for Mobile Communication (GSM) modulated 1800 MHz RFR exposure on t...
No differences between the baseline group and the exposed group (RFR) were observed. NMDA-NR1 expres...
ORAC assessment revealed a robust effect of RFR, however the other experiments revealed equivocal effects. Further studies examining the combination of ORAC with NMDA are warranted to elucidate more clearly the effect of RFR on the brain.
Show BibTeX
@article{p_2017_the_effect_of_1800_1576,
author = {Bodera P and Makarova K and Zawada K and Antkowiak B and Paluch M and Sobiczewska E and Sirav B and Siwicki AK and Stankiewicz W},
title = {The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states.},
year = {2017},
url = {https://www.sciencedirect.com/science/article/abs/pii/S075333221731394X},
}