Effect of Exposure to 900 MHz Radiofrequency Radiation on Intrachromosomal Recombination in pKZ1 Mice.
Sykes PJ, McCallum BD, Bangay MJ, Hooker AM, Morley AA. · 2001
View Original AbstractExposure to 900 MHz radiofrequency radiation for 25 days significantly reduced intrachromosomal recombination inversions below the spontaneous frequency in mouse spleen tissue.
Plain English Summary
Researchers studied the effect of pulsed 900 MHz radiofrequency radiation at 4 W/kg on somatic intrachromosomal recombination in the spleen of pKZ1 mice. Mice were exposed daily for 30 minutes to 900 MHz fields for 1, 5, or 25 days, and spleen sections were screened for DNA inversion events three days after the last exposure. There was no significant difference between control and treated groups in the 1- and 5-day exposure groups, but a significant reduction in inversions was found in the 25-day group.
Why This Matters
The researchers detected recombination events in spleen tissue by histochemical staining for a bacterial protein in cells where a transgene had undergone an inversion event. The authors suggested that exposure to RF radiation can lead to a perturbation in recombination frequency, which may have implications for recombination repair of DNA. The biological significance of a reduction below the spontaneous frequency was noted as not known. The authors noted that the number of mice in each treatment group was small, with groups of 10 or 20 animals, and called for repetition of the study with a larger number of animals to confirm the observations.
Exposure Details
- SAR
- 4 W/kg
- Source/Device
- 900 MHz
- Exposure Duration
- 30 min daily for 1, 5 or 25 days.
Exposure Context
This study used 4 W/kg for SAR (device absorption):
- 10x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We studied the effect of 4 W/kg pulsed 900 MHz RF radiation on somatic intrachromosomal recombination in the spleen in the pKZ1 recombination mutagenesis model.
Somatic intrachromosomal recombination inversion events were detected in spleen tissue of pKZ1 mice ...
There was no significant difference between the control and treated groups in the 1- and 5-day expos...
Show BibTeX
@article{pj_2001_effect_of_exposure_to_47,
author = {Sykes PJ and McCallum BD and Bangay MJ and Hooker AM and Morley AA.},
title = {Effect of Exposure to 900 MHz Radiofrequency Radiation on Intrachromosomal Recombination in pKZ1 Mice.},
year = {2001},
doi = {10.1667/0033-7587%282001%29156%5B0495%3AEOETMR%5D2.0.CO%3B2},
url = {http://www.rrjournal.org/doi/abs/10.1667/0033-7587%282001%29156%5B0495%3AEOETMR%5D2.0.CO%3B2},
}