Protein kinase C activity following exposure to magnetic field and phorbol ester
Authors not listed · 1998
A 60 Hz magnetic field combined with a low dose of PMA produced a greater decrease in cytosolic PKC and a larger increase in membrane PKC activity than PMA alone.
Plain English Summary
Researchers examined the separate and combined effects of 60 Hz magnetic fields and a phorbol ester on PKC activity in HL60 cells. Exposure to a 1.1 mT magnetic field alone or combined with 2 microM PMA for 1 h did not enhance PKC activity. In a second experiment, cells preexposed to 50 nM PMA for 45 min then exposed to both PMA and magnetic field for 15 min showed a greater decrease in cytosolic PKC activity and a larger increase in membrane activity than PMA treatment alone or PMA with sham exposure. The authors concluded that magnetic fields may act synergistically on an already activated pathway.
Why This Matters
The authors suggested that magnetic fields exert their effects by interacting with already functioning reactions or pathways. If correct, the mechanism question refocuses on how weak fields might enhance or depress a molecular reaction in progress.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{protein_kinase_c_activity_following_exposure_to_magnetic_field_and_phorbol_ester_ce1574,
author = {Unknown},
title = {Protein kinase C activity following exposure to magnetic field and phorbol ester},
year = {1998},
doi = {10.1002/(SICI)1521-186X(1998)19:8<469::AID-BEM4>3.0.CO;2-J},
}