Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation.

Bioeffects Seen

Nylund R, Leszczynski D · 2004

Cell phone radiation altered 38 proteins in blood vessel cells, disrupting cellular structure in ways that could affect cardiovascular function.

Plain English Summary

Summary written for general audiences

Researchers exposed human blood vessel cells to cell phone radiation and found that 38 different proteins changed their expression levels. Two of the affected proteins were vimentin, which helps maintain cell structure and shape. This suggests that cell phone radiation can disrupt the cellular skeleton that gives cells their form and helps them function properly.

Why This Matters

This research provides important mechanistic insight into how cell phone radiation affects living cells at the molecular level. The fact that GSM 900 MHz radiation - the same frequency used by many cell phones - altered the expression of nearly 40 proteins demonstrates that these exposures are biologically active, not biologically inert as the wireless industry often claims. The researchers' focus on vimentin is particularly significant because this protein is essential for maintaining cellular structure and enabling critical functions like cell division and migration. When the cellular skeleton is disrupted, it can cascade into broader physiological problems. What makes this study especially relevant is that it examines endothelial cells, which line our blood vessels and play crucial roles in cardiovascular health. The science demonstrates that everyday exposures from mobile phones can trigger measurable biological changes at the cellular level, adding to the growing body of evidence that these technologies are not as safe as we've been led to believe.

Exposure Information

Specific exposure levels were not quantified in this study. The study examined exposure from: GSM 900 MHz

Study Details

The human endothelial cell line EA.hy926 was exposed to mobile phone radiation and the effect on protein expression was examined using two-dimensional electrophoresis (2-DE).

Up to 38 various proteins have statistically significantly altered their expression levels following...

This finding supports our earlier presented working hypothesis which indicated that the mobile phone radiation might affect the cytoskeleton and might have an effect on the physiological functions that are regulated by the cytoskeleton.

Cite This Study

Nylund R, Leszczynski D (2004). Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation. Proteomics 4:1359-1365, 2004.

Show BibTeX

@article{r_2004_proteomics_analysis_of_human_2474,
  author = {Nylund R and Leszczynski D},
  title = {Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation.},
  year = {2004},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/15188403/},
}

PubMed: 15188403

Cited By (102 papers)

Impacts of radio-frequency electromagneticfield (RF-EMF) from cell phone towers and wireless devices on biosystem and ecosystem – a review
S. Sivani, D. Sudarsanam (2012) - 83 citations
Influential
Cell phones: modern man's nemesis?
K. Makker et al. (2009) - 78 citations
Influential
Effect of 3G Cell Phone Exposure with Computer Controlled 2-D Stepper Motor on Non-thermal Activation of the hsp27/p38MAPK Stress Pathway in Rat Brain
K. Kesari et al. (2014) - 61 citations
Influential
Biological monitoring of non‐thermal effects of mobile phone radiation: recent approaches and challenges
M. Gaestel (2009) - 50 citations
Influential
Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells
R. Nylund et al. (2010) - 31 citations
Influential
Five years later: The current status of the use of proteomics and transcriptomics in EMF research
Dariusz Leszczyński et al. (2012) - 30 citations
Influential
Proteomic Analysis of the Response of Human Endothelial Cell Line EA.hy926 to 1800 GSM Mobile Phone Radiation
R. Nylund et al. (2009) - 22 citations
Influential
Effects of radiofrequency-modulated electromagnetic fields on proteome.
Dariusz Leszczyński (2013) - 10 citations
Influential
Complementing the Genome with an “Exposome”: The Outstanding Challenge of Environmental Exposure Measurement in Molecular Epidemiology
C. Wild (2005) - 1,917 citations
Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: an in vitro pilot study.
A. Agarwal et al. (2009) - 435 citations

View all 102 citing papers on Semantic Scholar

Quick Questions About This Study

Yes, GSM 900 MHz radiation significantly altered 38 different proteins in human blood vessel cells. Researchers identified changes in vimentin proteins, which help maintain cell structure. This suggests cell phone radiation can disrupt the cellular skeleton that gives cells their shape and function.

Research found that GSM 900 MHz radiation affected vimentin protein isoforms in human endothelial cells. Vimentin helps maintain cellular structure and shape. When these proteins are disrupted, it can impact how cells maintain their form and carry out normal functions.

A 2004 study found that 38 different proteins showed statistically significant changes in expression levels after exposure to GSM 900 MHz radiation. Four proteins were specifically identified, including two forms of the structural protein vimentin in blood vessel cells.

Yes, GSM 900 MHz radiation appears to affect the cellular skeleton. The study found changes in vimentin proteins, which are key components of the cytoskeleton that helps cells maintain their shape and supports various cellular functions regulated by this structural framework.

Human endothelial cells (EA.hy926 blood vessel cells) showed significant protein expression changes when exposed to GSM 900 MHz radiation. The study identified alterations in 38 proteins, particularly affecting vimentin, which suggests disruption to cellular structure and function.