Chronic exposure to 50 Hz magnetic fields causes a significant weakening of antioxidant defence systems in aged rat brain
Falone S, Mirabilio A, Carbone MC, Zimmitti V, Di Loreto S, Mariggiò MA, Mancinelli R, Di Ilio C, Amicarelli F. · 2008
View Original AbstractAged rats continuously exposed to a 50 Hz magnetic field showed a significant decrease in major antioxidant enzymatic activities in the brain.
Plain English Summary
Researchers continuously exposed female Sprague-Dawley rats to a sinusoidal 50 Hz, 0.1 mT magnetic field for 10 days. The study examined antioxidant protection systems and neurotrophic support in brain cortices, as a function of the age of the subjects. Exposure significantly affected antioxidant capability in both young and aged animals, but in opposite ways. The researchers suggested that exposure to these fields may act as a risk factor for oxidative stress-based nervous system pathologies associated with ageing.
Why This Matters
The study's aim was to establish whether the ageing process can increase susceptibility towards ELF-MF-mediated pro-oxidative challenges. Exposed young individuals enhanced their neurotrophic signalling and antioxidant enzymatic defence against a possible ELF-MF-mediated increase in oxygen radical species. In contrast, aged subjects were not capable of increasing their defences in response to ELF-MF treatment and instead showed a significant decrease in the major antioxidant enzymatic activities. Brain cortices were specifically chosen for analysis due to the high susceptibility of neuronal cells to oxidative injury.
Exposure Details
- Magnetic Field
- 0.1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 10 days
Exposure Context
This study used 0.1 mT for magnetic fields:
- 5Kx above the Building Biology guideline of 0.2 mG
- 1Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
the aim of this study was to establish whether the ageing process can increase susceptibility towards widely present ELF-MF-mediated pro-oxidative challenges.
To this end, female Sprague–Dawley rats were continuously exposed to a sinusoidal 50 Hz, 0.1 mT magn...
Our results indicated that ELF-MF exposure significantly affects anti-oxidative capability, both in ...
In conclusion, our data seem to suggest that the exposure to ELF-MFs may act as a risk factor for the occurrence of oxidative stress-based nervous system pathologies associated with ageing.
Show BibTeX
@article{s_2008_chronic_exposure_to_50_248,
author = {Falone S and Mirabilio A and Carbone MC and Zimmitti V and Di Loreto S and Mariggiò MA and Mancinelli R and Di Ilio C and Amicarelli F.},
title = {Chronic exposure to 50 Hz magnetic fields causes a significant weakening of antioxidant defence systems in aged rat brain},
year = {2008},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1357272508002161},
}